Cited 20 times in
Glomerular crescents are responsible for chronic graft dysfunction in post-transplant IgA nephropathy
DC Field | Value | Language |
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dc.contributor.author | 김유선 | - |
dc.contributor.author | 정현주 | - |
dc.date.accessioned | 2015-07-14T16:40:50Z | - |
dc.date.available | 2015-07-14T16:40:50Z | - |
dc.date.issued | 2004 | - |
dc.identifier.issn | 1320-5463 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/111374 | - |
dc.description.abstract | Information is limited regarding the histological features related to chronic graft dysfunction and failure in patients with IgA nephropathy developing after renal transplantation. The prevalence and significance of glomerular crescents in post-transplant IgAN including recurrent, de novo and transmitted forms (TxIgAN), were studied. Renal morphology was evaluated in 71 patients of TxIgAN, obtained at more than 6 months post-transplant, and compared with regard to the presence (C-TxIgAN) or absence (N-TxIgAN) of glomerular crescents. Crescents were demonstrated in 12 samples of 10 patients (14.1%). The percentages of crescents were from 4.8% to 83.3% (median, 28.6%) in each sample. Ten samples of C-TxIgAN had cellular to fibrocellular crescents, and four of these were associated with diffuse mesangial proliferation. Serum creatinine levels and the frequency of nephrotic range proteinuria at the time of biopsy and the degree of interstitial inflammation were significantly different in the two groups. Graft survival after allograft biopsies was significantly lower in C-TxIgAN (P = 0.0017). Chronic rejection was a major cause of graft loss in N-TxIgAN (31.8%), whereas TxIgAN was the major cause in C-TxIgAN (66.7%). In conclusion, the current study suggests that glomerular crescents are not rare and that they are responsible for chronic graft dysfunction in TxIgAN patients. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 837~842 | - |
dc.relation.isPartOf | PATHOLOGY INTERNATIONAL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Creatinine/blood | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Glomerulonephritis, IGA/surgery | - |
dc.subject.MESH | Graft Rejection/drug therapy | - |
dc.subject.MESH | Graft Rejection/pathology* | - |
dc.subject.MESH | Graft Survival | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Immunosuppressive Agents/therapeutic use | - |
dc.subject.MESH | Kidney Glomerulus/pathology* | - |
dc.subject.MESH | Kidney Transplantation* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Microscopy, Fluorescence | - |
dc.subject.MESH | Proteinuria/pathology | - |
dc.subject.MESH | Treatment Outcome | - |
dc.title | Glomerular crescents are responsible for chronic graft dysfunction in post-transplant IgA nephropathy | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pathology (병리학) | - |
dc.contributor.googleauthor | Hyeon Joo Jeong | - |
dc.contributor.googleauthor | Yu Seun Kim | - |
dc.contributor.googleauthor | Kiil Park | - |
dc.contributor.googleauthor | Dae Suk Han | - |
dc.contributor.googleauthor | Ho Yung Lee | - |
dc.contributor.googleauthor | Kyu Hun Choi | - |
dc.contributor.googleauthor | Myoung Soo Kim | - |
dc.contributor.googleauthor | Soon Il Kim | - |
dc.contributor.googleauthor | Ki Hwan Kwon | - |
dc.identifier.doi | 10.1111/j.1440-1827.2004.01751.x | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.relation.journalcode | J02473 | - |
dc.identifier.eissn | 1440-1827 | - |
dc.identifier.pmid | 15533226 | - |
dc.identifier.url | http://onlinelibrary.wiley.com/doi/10.1111/j.1440-1827.2004.01751.x/abstract | - |
dc.subject.keyword | glomerular crescents | - |
dc.subject.keyword | graft survival | - |
dc.subject.keyword | IgA nephro-pathy | - |
dc.subject.keyword | recurrence | - |
dc.subject.keyword | transplantation | - |
dc.contributor.alternativeName | Kim, Yu Seun | - |
dc.contributor.alternativeName | Jeong, Hyeon Joo | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 54 | - |
dc.citation.number | 11 | - |
dc.citation.startPage | 837 | - |
dc.citation.endPage | 842 | - |
dc.identifier.bibliographicCitation | PATHOLOGY INTERNATIONAL, Vol.54(11) : 837-842, 2004 | - |
dc.identifier.rimsid | 35778 | - |
dc.type.rims | ART | - |
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