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Cited 11 times in

The myoepithelial cell differentiation of mucoepidermoid carcinoma in a collagen gel-based coculture model

DC FieldValueLanguage
dc.contributor.author김진-
dc.contributor.author육종인-
dc.contributor.author차인호-
dc.date.accessioned2015-07-14T16:39:57Z-
dc.date.available2015-07-14T16:39:57Z-
dc.date.issued2004-
dc.identifier.issn0904-2512-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/111344-
dc.description.abstractBACKGROUND: Mucoepidermoid carcinomas (MECs) are the most common malignant tumor of the salivary glands; however, the histogenesis of MECs has been still controversial. This study was undertaken to investigate the histogenesis of MECs by the examination of their collagen gel-based coculture tissue and transplanted tumors. METHODS: Two cell lines from a primary and a metastatic MECs were established and characterized by the mutational analysis of the p53 gene and in vivo tumorigenicity in athymic nude mice. Collagen gel-based organotypic cocultures were performed, and the ultrastructural and immunohistochemical findings were examined. RESULTS: Two cell lines demonstrated p53 point mutation at the same codon. A metastatic cell line of MEC showed in vivo tumorigenicity. Transplanted tumors and the collagen gel-based culture tissues showed poorly differentiated squamous cell carcinomas devoid of mucous cell differentiation; however, they disclosed the differentiation of myoepithelial cells. CONCLUSIONS: MECs appear to be centered on the squamous cell differentiation, and the specific differentiation of myoepithelial or mucous cells seems to be modulated by the property of microenvironment.-
dc.description.statementOfResponsibilityopen-
dc.format.extent237~242-
dc.relation.isPartOfJOURNAL OF ORAL PATHOLOGY & MEDICINE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESH3T3 Cells-
dc.subject.MESHActins/analysis-
dc.subject.MESHAdult-
dc.subject.MESHAnimals-
dc.subject.MESHCarcinoma, Mucoepidermoid/pathology*-
dc.subject.MESHCarcinoma, Mucoepidermoid/secondary-
dc.subject.MESHCarcinoma, Squamous Cell/pathology-
dc.subject.MESHCell Differentiation-
dc.subject.MESHCell Line, Tumor-
dc.subject.MESHCoculture Techniques-
dc.subject.MESHCodon/genetics-
dc.subject.MESHCollagen-
dc.subject.MESHCulture Media-
dc.subject.MESHEpithelial Cells/pathology-
dc.subject.MESHGenes, p53/genetics-
dc.subject.MESHHumans-
dc.subject.MESHKeratins/analysis-
dc.subject.MESHLymphatic Metastasis/pathology-
dc.subject.MESHMale-
dc.subject.MESHMice-
dc.subject.MESHMice, Inbred BALB C-
dc.subject.MESHMice, Nude-
dc.subject.MESHMuscle, Smooth/pathology*-
dc.subject.MESHNeoplasm Transplantation-
dc.subject.MESHPoint Mutation/genetics-
dc.subject.MESHTongue Neoplasms/pathology-
dc.titleThe myoepithelial cell differentiation of mucoepidermoid carcinoma in a collagen gel-based coculture model-
dc.typeArticle-
dc.contributor.collegeCollege of Dentistry (치과대학)-
dc.contributor.departmentDept. of Oral Pathology (구강병리학)-
dc.contributor.googleauthorJong In Yook-
dc.contributor.googleauthorSeoung Ae Lee-
dc.contributor.googleauthorJin Kim-
dc.contributor.googleauthorIn Ho Cha-
dc.contributor.googleauthorJung Huh-
dc.contributor.googleauthorYong Chan Chun-
dc.identifier.doi10.1111/j.0904-2512.2004.00056.x-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.relation.journalcodeJ01665-
dc.identifier.eissn1600-0714-
dc.identifier.pmid15061712-
dc.identifier.urlhttp://onlinelibrary.wiley.com/doi/10.1111/j.0904-2512.2004.00056.x/abstract-
dc.subject.keywordcollagen gel‐based coculture-
dc.subject.keywordmicroenvironment-
dc.subject.keywordmucoepidermoid carcinoma-
dc.subject.keywordmucous cells-
dc.subject.keywordmyoepithelial cells-
dc.subject.keywordsquamous cells-
dc.subject.keywordtransplantation-
dc.contributor.alternativeNameKim, Jin-
dc.contributor.alternativeNameYook, Jong In-
dc.contributor.alternativeNameCha, In Ho-
dc.rights.accessRightsnot free-
dc.citation.volume33-
dc.citation.number4-
dc.citation.startPage237-
dc.citation.endPage242-
dc.identifier.bibliographicCitationJOURNAL OF ORAL PATHOLOGY & MEDICINE, Vol.33(4) : 237-242, 2004-
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Oral Pathology (구강병리학교실) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Oral and Maxillofacial Surgery (구강악안면외과학교실) > 1. Journal Papers

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