Cited 301 times in
Early- and Late-onset Complications of the Ketogenic Diet for Intractable Epilepsy
DC Field | Value | Language |
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dc.contributor.author | 김흥동 | - |
dc.contributor.author | 강훈철 | - |
dc.date.accessioned | 2015-07-14T16:39:52Z | - |
dc.date.available | 2015-07-14T16:39:52Z | - |
dc.date.issued | 2004 | - |
dc.identifier.issn | 0013-9580 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/111341 | - |
dc.description.abstract | PURPOSE: This study was undertaken to evaluate the exact limitations of the ketogenic diet (KD) and to collect data on the prevention and management of its risks. METHODS: Patients (129) who were on the KD from July 1995 to October 2001 at our epilepsy center were assessed in the study. Early-onset (within 4 weeks of the commencement of the KD until stabilization) and late-onset complications (occurring after 4 weeks) were reviewed. RESULTS: The most common early-onset complication was dehydration, especially in patients who started the KD with initial fasting. Gastrointestinal (GI) disturbances, such as nausea/vomiting, diarrhea, and constipation, also were frequently noted, sometimes associated with gastritis and fat intolerance. Other early-onset complications, in order of frequency, were hypertriglyceridemia, transient hyperuricemia, hypercholesterolemia, various infectious diseases, symptomatic hypoglycemia, hypoproteinemia, hypomagnesemia, repetitive hyponatremia, low concentrations of high-density lipoprotein, lipoid pneumonia due to aspiration, hepatitis, acute pancreatitis, and persistent metabolic acidosis. Late-onset complications also included osteopenia, renal stones, cardiomyopathy, secondary hypocarnitinemia, and iron-deficiency anemia. Most early- and late-onset complications were transient and successfully managed by careful follow-up and conservative strategies. However, 22 (17.1%) patients ceased the KD because of various kinds of serious complications, and four (3.1%) patients died during the KD, two of sepsis, one of cardiomyopathy, and one of lipoid pneumonia. CONCLUSIONS: Most complications of the KD are transient and can be managed easily with various conservative treatments. However, life-threatening complications should be monitored closely during follow-up. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 1116~1123 | - |
dc.relation.isPartOf | EPILEPSIA | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adolescent | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Anticonvulsants/adverse effects | - |
dc.subject.MESH | Anticonvulsants/therapeutic use | - |
dc.subject.MESH | Child | - |
dc.subject.MESH | Child, Preschool | - |
dc.subject.MESH | Combined Modality Therapy | - |
dc.subject.MESH | Dehydration/etiology | - |
dc.subject.MESH | Dietary Carbohydrates/administration & dosage | - |
dc.subject.MESH | Dietary Fats/administration & dosage* | - |
dc.subject.MESH | Dietary Fats/adverse effects* | - |
dc.subject.MESH | Dietary Fats/metabolism | - |
dc.subject.MESH | Dietary Proteins/administration & dosage | - |
dc.subject.MESH | Epilepsy/diet therapy* | - |
dc.subject.MESH | Epilepsy/drug therapy | - |
dc.subject.MESH | Epilepsy/metabolism | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Food, Formulated/adverse effects | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Infant | - |
dc.subject.MESH | Ketones/metabolism | - |
dc.subject.MESH | Ketosis/complications* | - |
dc.subject.MESH | Ketosis/etiology | - |
dc.subject.MESH | Ketosis/metabolism | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Survival Analysis | - |
dc.title | Early- and Late-onset Complications of the Ketogenic Diet for Intractable Epilepsy | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pediatrics (소아과학) | - |
dc.contributor.googleauthor | Hoon Chul Kang | - |
dc.contributor.googleauthor | Da Eun Chung | - |
dc.contributor.googleauthor | Heung Dong Kim | - |
dc.contributor.googleauthor | Dong Wook Kim | - |
dc.identifier.doi | 10.1111/j.0013-9580.2004.10004.x | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.relation.journalcode | J00793 | - |
dc.identifier.eissn | 1528-1167 | - |
dc.identifier.pmid | 15329077 | - |
dc.identifier.url | http://onlinelibrary.wiley.com/doi/10.1111/j.0013-9580.2004.10004.x/abstract | - |
dc.subject.keyword | Early onset | - |
dc.subject.keyword | Late onset | - |
dc.subject.keyword | Complications | - |
dc.subject.keyword | Ketogenic diet | - |
dc.subject.keyword | Intractable epilepsy | - |
dc.contributor.alternativeName | Kim, Heung Dong | - |
dc.contributor.alternativeName | Kang, Hoon Chul | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 45 | - |
dc.citation.number | 9 | - |
dc.citation.startPage | 1116 | - |
dc.citation.endPage | 1123 | - |
dc.identifier.bibliographicCitation | EPILEPSIA, Vol.45(9) : 1116-1123, 2004 | - |
dc.identifier.rimsid | 35989 | - |
dc.type.rims | ART | - |
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