4 241

Cited 197 times in

Early- and Late-onset Complications of the Ketogenic Diet for Intractable Epilepsy

DC FieldValueLanguage
dc.contributor.author김흥동-
dc.contributor.author강훈철-
dc.date.accessioned2015-07-14T16:39:52Z-
dc.date.available2015-07-14T16:39:52Z-
dc.date.issued2004-
dc.identifier.issn0013-9580-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/111341-
dc.description.abstractPURPOSE: This study was undertaken to evaluate the exact limitations of the ketogenic diet (KD) and to collect data on the prevention and management of its risks. METHODS: Patients (129) who were on the KD from July 1995 to October 2001 at our epilepsy center were assessed in the study. Early-onset (within 4 weeks of the commencement of the KD until stabilization) and late-onset complications (occurring after 4 weeks) were reviewed. RESULTS: The most common early-onset complication was dehydration, especially in patients who started the KD with initial fasting. Gastrointestinal (GI) disturbances, such as nausea/vomiting, diarrhea, and constipation, also were frequently noted, sometimes associated with gastritis and fat intolerance. Other early-onset complications, in order of frequency, were hypertriglyceridemia, transient hyperuricemia, hypercholesterolemia, various infectious diseases, symptomatic hypoglycemia, hypoproteinemia, hypomagnesemia, repetitive hyponatremia, low concentrations of high-density lipoprotein, lipoid pneumonia due to aspiration, hepatitis, acute pancreatitis, and persistent metabolic acidosis. Late-onset complications also included osteopenia, renal stones, cardiomyopathy, secondary hypocarnitinemia, and iron-deficiency anemia. Most early- and late-onset complications were transient and successfully managed by careful follow-up and conservative strategies. However, 22 (17.1%) patients ceased the KD because of various kinds of serious complications, and four (3.1%) patients died during the KD, two of sepsis, one of cardiomyopathy, and one of lipoid pneumonia. CONCLUSIONS: Most complications of the KD are transient and can be managed easily with various conservative treatments. However, life-threatening complications should be monitored closely during follow-up.-
dc.description.statementOfResponsibilityopen-
dc.format.extent1116~1123-
dc.relation.isPartOfEPILEPSIA-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdolescent-
dc.subject.MESHAdult-
dc.subject.MESHAnticonvulsants/adverse effects-
dc.subject.MESHAnticonvulsants/therapeutic use-
dc.subject.MESHChild-
dc.subject.MESHChild, Preschool-
dc.subject.MESHCombined Modality Therapy-
dc.subject.MESHDehydration/etiology-
dc.subject.MESHDietary Carbohydrates/administration & dosage-
dc.subject.MESHDietary Fats/administration & dosage*-
dc.subject.MESHDietary Fats/adverse effects*-
dc.subject.MESHDietary Fats/metabolism-
dc.subject.MESHDietary Proteins/administration & dosage-
dc.subject.MESHEpilepsy/diet therapy*-
dc.subject.MESHEpilepsy/drug therapy-
dc.subject.MESHEpilepsy/metabolism-
dc.subject.MESHFemale-
dc.subject.MESHFood, Formulated/adverse effects-
dc.subject.MESHHumans-
dc.subject.MESHInfant-
dc.subject.MESHKetones/metabolism-
dc.subject.MESHKetosis/complications*-
dc.subject.MESHKetosis/etiology-
dc.subject.MESHKetosis/metabolism-
dc.subject.MESHMale-
dc.subject.MESHSurvival Analysis-
dc.titleEarly- and Late-onset Complications of the Ketogenic Diet for Intractable Epilepsy-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Pediatrics (소아과학)-
dc.contributor.googleauthorHoon Chul Kang-
dc.contributor.googleauthorDa Eun Chung-
dc.contributor.googleauthorHeung Dong Kim-
dc.contributor.googleauthorDong Wook Kim-
dc.identifier.doi10.1111/j.0013-9580.2004.10004.x-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.relation.journalcodeJ00793-
dc.identifier.eissn1528-1167-
dc.identifier.pmid15329077-
dc.identifier.urlhttp://onlinelibrary.wiley.com/doi/10.1111/j.0013-9580.2004.10004.x/abstract-
dc.subject.keywordEarly onset-
dc.subject.keywordLate onset-
dc.subject.keywordComplications-
dc.subject.keywordKetogenic diet-
dc.subject.keywordIntractable epilepsy-
dc.contributor.alternativeNameKim, Heung Dong-
dc.contributor.alternativeNameKang, Hoon Chul-
dc.rights.accessRightsnot free-
dc.citation.volume45-
dc.citation.number9-
dc.citation.startPage1116-
dc.citation.endPage1123-
dc.identifier.bibliographicCitationEPILEPSIA, Vol.45(9) : 1116-1123, 2004-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.