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Overexpression of LIM kinase 1 renders resistance to apoptosis in PC12 cells by inhibition of caspase activation

Authors
 E. Yang  ;  H. Kim  ;  I.-H. Choi  ;  S.-J. Kim  ;  H. Yoon  ;  J.-S. Shin  ;  J. Lee 
Citation
 Cellular and Molecular Neurobiology, Vol.24(2) : 181-192, 2004 
Journal Title
 Cellular and Molecular Neurobiology 
ISSN
 0272-4340 
Issue Date
2004
Abstract
LIM kinases (LIMKs) regulate actin polymerization by phosphorylating cofilin and are predominantly expressed in neural tissue. In this study, the effect of LIMK1 overexpression in PC12 cell apoptosis was investigated. PC12 cells overexpressing the wild-type LIMK1 were more resistant to serum-withdrawal-induced cell death and the level of caspase 3 activation in these cells was lower than in the control PC12 cells or than in the PC12 cells expressing a mutant LIMK1 lacking the kinase domain. The inhibition of JNK activation was observed in the PC12 cells overexpressing the wild-type LIMK1 after serum withdrawal. These results suggest that the LIMK1 might allow resistance to apoptosis in PC12 cells by inhibiting JNK activation
Full Text
http://link.springer.com/article/10.1023/B:CEMN.0000018615.84358.33
DOI
10.1023/B:CEMN.0000018615.84358.33
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Microbiology (미생물학교실) > 1. Journal Papers
Yonsei Authors
Kim, Se Jong(김세종)
Shin, Jeon Soo(신전수) ORCID logo https://orcid.org/0000-0002-8294-3234
Choi, In Hong(최인홍) ORCID logo https://orcid.org/0000-0001-9851-0137
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/111279
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