Cited 19 times in
Patterns of treatment failure following radiotherapy with combination chemotherapy for patients with high-risk stage IIB cervical carcinoma
DC Field | Value | Language |
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dc.contributor.author | 권자영 | - |
dc.contributor.author | 김귀언 | - |
dc.contributor.author | 김상운 | - |
dc.contributor.author | 김성훈 | - |
dc.contributor.author | 박찬규 | - |
dc.date.accessioned | 2015-07-14T16:37:50Z | - |
dc.date.available | 2015-07-14T16:37:50Z | - |
dc.date.issued | 2004 | - |
dc.identifier.issn | 1341-9625 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/111274 | - |
dc.description.abstract | BACKGROUND: To evaluate the patterns of treatment failure in patients with stage IIB cervical carcinoma with high-risk factors following radiotherapy given concurrently with combination chemotherapy. METHODS: A retrospective analysis of 349 patients with stage IIB cervical carcinoma with high-risk factors (lesion size >/= 4 cm, lymph node metastasis, high-risk cell type) treated by radiotherapy and cisplatin-based chemotherapy was performed. Sites of treatment failure were categorized as pelvic, pelvic plus distant metastases, and distant metastases alone. Pelvic failure included local and pelvic nodal failures. RESULTS: Of the 349 patients, treatment failure occurred in 79 patients (22.6%). Forty-six (13.2%) had persistent disease and 33 (9.5%) had recurrent disease. Among these 79 patients, overall pelvic failure was observed in 67%, of whom 72% had local failure; 19%, pelvic nodal failure; and 9%, local with pelvic nodal failure. Incidences of distant metastases alone and pelvic with distant metastases were 24% and 9%. In the 26 patients with distant metastases either alone or combined with pelvic failure, the most frequent metastatic region was the paraaortic lymph node (50%). The distant metastasis rate was 6.5% (19/289) in the pelvic tumor control group and 11.6% (7/60) in the pelvic failure group. Pelvic failure was the most frequent failure in the group with tumor size of 4 cm or more, whereas, for the positive-lymph-node group, distant metastasis was most frequent and metastases to paraaortic lymph nodes were common. The incidences of pelvic failure alone and distant metastases were similar in the high-risk cell-type group, and the distant metastasis regions were mostly paraaortic lymph nodes. CONCLUSION: Although systemic chemotherapy was administered concurrently with radiotherapy, the incidence of pelvic failure was highest, followed by paraaortic lymph node metastases, in patients with stage IIB cervical carcinoma with high-risk factors, following radiotherapy with combination chemotherapy. To evaluate the patterns of treatment failure in patients with stage IIB cervical carcinoma with high-risk factors following radiotherapy given concurrently with combination chemotherapy. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 120~124 | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Antineoplastic Combined Chemotherapy Protocols/therapeutic use* | - |
dc.subject.MESH | Brachytherapy | - |
dc.subject.MESH | Carcinoma/pathology | - |
dc.subject.MESH | Carcinoma/therapy* | - |
dc.subject.MESH | Combined Modality Therapy | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Neoplasm Metastasis | - |
dc.subject.MESH | Neoplasm Staging | - |
dc.subject.MESH | Radiotherapy/methods* | - |
dc.subject.MESH | Retrospective Studies | - |
dc.subject.MESH | Treatment Failure | - |
dc.subject.MESH | Uterine Cervical Neoplasms/pathology | - |
dc.subject.MESH | Uterine Cervical Neoplasms/therapy* | - |
dc.title | Patterns of treatment failure following radiotherapy with combination chemotherapy for patients with high-risk stage IIB cervical carcinoma | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Radiation Oncology (방사선종양학) | - |
dc.contributor.googleauthor | Tchan-Kyu Park | - |
dc.contributor.googleauthor | Ja-Young Kwon | - |
dc.contributor.googleauthor | Gwi Eon Kim | - |
dc.contributor.googleauthor | Soo-Nyung Kim | - |
dc.contributor.googleauthor | Sung-Hoon Kim | - |
dc.contributor.googleauthor | Sang-Wun Kim | - |
dc.identifier.doi | 10.1007/s10147-003-0378-9 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.relation.journalcode | J01097 | - |
dc.identifier.eissn | 1437-7772 | - |
dc.identifier.pmid | 15108044 | - |
dc.identifier.url | http://link.springer.com/article/10.1007%2Fs10147-003-0378-9 | - |
dc.contributor.alternativeName | Kwon, Ja Young | - |
dc.contributor.alternativeName | Kim, Gwi Eon | - |
dc.contributor.alternativeName | Kim, Sang Wun | - |
dc.contributor.alternativeName | Kim, Sung Hoon | - |
dc.contributor.alternativeName | Park, Chan Gyu | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 9 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 120 | - |
dc.citation.endPage | 124 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY, Vol.9(2) : 120-124, 2004 | - |
dc.identifier.rimsid | 35951 | - |
dc.type.rims | ART | - |
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