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Comparison of the Effects of Nicardipine and Sodium Nitroprusside for Control of Increased Blood Pressure after Coronary Artery Bypass Graft Surgery

Authors
 YL KWAK  ;  YJ OH  ;  SO BANG  ;  JH LEE  ;  SM JEONG  ;  YW HONG 
Citation
 JOURNAL OF INTERNATIONAL MEDICAL RESEARCH, Vol.32(4) : 342-350, 2004 
Journal Title
 JOURNAL OF INTERNATIONAL MEDICAL RESEARCH 
ISSN
 0300-0605 
Issue Date
2004
MeSH
Adult ; Aged ; Blood Pressure*/drug effects ; Catecholamines/blood ; Coronary Artery Bypass/methods* ; Female ; Humans ; Hypertension/therapy* ; Male ; Middle Aged ; Nicardipine/pharmacology* ; Nitroprusside/pharmacology* ; Postoperative Complications ; Time Factors ; Vasodilator Agents/pharmacology
Keywords
Coronary artery bypass graft surgery ; Hypertension ; Nicardipine ; Sodium nitroprusside
Abstract
We compared the haemodynamic effects of nicardipine and sodium nitroprusside after coronary artery bypass graft surgery. When post-surgery systolic blood pressure reached > 150 mmHg, patients were randomly given nicardipine (N group, n = 26) or sodium nitroprusside (S group, n = 21). The drugs were infused at a rate of 2 microg/kg per min for 10 min. If the target blood pressure (120-140 mmHg) was not achieved, the infusion rate was increased by 1 microg/kg per min every 10 min. Cardiac and stroke volume indices had increased significantly in the N group after 10 min and in both groups after 60 min. The infusion duration and total dose of drug were significantly lower in the N group compared with the S group. Nicardipine infusion controlled post-operative hypertension more rapidly and was superior to sodium nitroprusside in maintaining left ventricular performance immediately after drug infusion.
Full Text
http://imr.sagepub.com/content/32/4/342
DOI
10.1177/147323000403200401
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 1. Journal Papers
Yonsei Authors
Kwak, Young Lan(곽영란) ORCID logo https://orcid.org/0000-0002-2984-9927
Bang, Sou Ouk(방서욱)
Oh, Young Jun(오영준) ORCID logo https://orcid.org/0000-0002-6258-5695
Lee, Jong Wha(이종화)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/111186
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