Cited 194 times in
Intensified and protective CD4+ T cell immunity in mice with anti-dendritic cell HIV gag fusion antibody vaccine.
DC Field | Value | Language |
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dc.contributor.author | 박채규 | - |
dc.date.accessioned | 2015-06-10T13:09:36Z | - |
dc.date.available | 2015-06-10T13:09:36Z | - |
dc.date.issued | 2006 | - |
dc.identifier.issn | 0022-1007 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/111119 | - |
dc.description.abstract | Current human immunodeficiency virus (HIV) vaccine approaches emphasize prime boost strategies comprising multiple doses of DNA vaccine and recombinant viral vectors. We are developing a protein-based approach that directly harnesses principles for generating T cell immunity. Vaccine is delivered to maturing dendritic cells in lymphoid tissue by engineering protein antigen into an antibody to DEC-205, a receptor for antigen presentation. Here we characterize the CD4+ T cell immune response to HIV gag and compare efficacy with other vaccine strategies in a single dose. DEC-205-targeted HIV gag p24 or p41 induces stronger CD4+ T cell immunity relative to high doses of gag protein, HIV gag plasmid DNA, or recombinant adenovirus-gag. High frequencies of interferon (IFN)-gamma- and interleukin 2-producing CD4+ T cells are elicited, including double cytokine-producing cells. In addition, the response is broad because the primed mice respond to an array of peptides in different major histocompatibility complex haplotypes. Long-lived T cell memory is observed. After subcutaneous vaccination, CD4+ and IFN-gamma-dependent protection develops to a challenge with recombinant vaccinia-gag virus at a mucosal surface, the airway. We suggest that a DEC-targeted vaccine, in part because of an unusually strong and protective CD4+ T cell response, will improve vaccine efficacy as a stand-alone approach or with other modalities. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 607~617 | - |
dc.relation.isPartOf | JOURNAL OF EXPERIMENTAL MEDICINE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | AIDS Vaccines/administration & dosage | - |
dc.subject.MESH | AIDS Vaccines/genetics | - |
dc.subject.MESH | AIDS Vaccines/immunology* | - |
dc.subject.MESH | Adenoviridae | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Antibodies, Monoclonal/administration & dosage | - |
dc.subject.MESH | Antibodies, Monoclonal/genetics | - |
dc.subject.MESH | Antibodies, Monoclonal/immunology | - |
dc.subject.MESH | Antigen Presentation/drug effects | - |
dc.subject.MESH | Antigen Presentation/immunology | - |
dc.subject.MESH | Antigens, CD/genetics | - |
dc.subject.MESH | Antigens, CD/immunology* | - |
dc.subject.MESH | CD4-Positive T-Lymphocytes/immunology* | - |
dc.subject.MESH | Dendritic Cells/immunology* | - |
dc.subject.MESH | Dose-Response Relationship, Immunologic | - |
dc.subject.MESH | Gene Products, gag/administration & dosage | - |
dc.subject.MESH | Gene Products, gag/genetics | - |
dc.subject.MESH | Gene Products, gag/immunology* | - |
dc.subject.MESH | Genetic Vectors/administration & dosage | - |
dc.subject.MESH | Genetic Vectors/genetics | - |
dc.subject.MESH | Genetic Vectors/immunology | - |
dc.subject.MESH | HIV-1/genetics | - |
dc.subject.MESH | HIV-1/immunology* | - |
dc.subject.MESH | Haplotypes/genetics | - |
dc.subject.MESH | Haplotypes/immunology | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Immunity, Mucosal/drug effects | - |
dc.subject.MESH | Immunity, Mucosal/immunology | - |
dc.subject.MESH | Immunologic Memory/drug effects | - |
dc.subject.MESH | Immunologic Memory/immunology | - |
dc.subject.MESH | Injections, Subcutaneous | - |
dc.subject.MESH | Lectins, C-Type/deficiency | - |
dc.subject.MESH | Lectins, C-Type/genetics | - |
dc.subject.MESH | Lectins, C-Type/immunology* | - |
dc.subject.MESH | Major Histocompatibility Complex/immunology | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Mice, Inbred BALB C | - |
dc.subject.MESH | Mice, Inbred C3H | - |
dc.subject.MESH | Mice, Knockout | - |
dc.subject.MESH | Minor Histocompatibility Antigens | - |
dc.subject.MESH | Receptors, Cell Surface/deficiency | - |
dc.subject.MESH | Receptors, Cell Surface/genetics | - |
dc.subject.MESH | Receptors, Cell Surface/immunology* | - |
dc.subject.MESH | Recombinant Fusion Proteins/administration & dosage | - |
dc.subject.MESH | Recombinant Fusion Proteins/genetics | - |
dc.subject.MESH | Recombinant Fusion Proteins/immunology | - |
dc.subject.MESH | Vaccinia virus | - |
dc.subject.MESH | Substances | - |
dc.subject.MESH | AIDS Vaccines | - |
dc.subject.MESH | Antibodies, Monoclonal | - |
dc.subject.MESH | Antigens, CD | - |
dc.subject.MESH | DEC-205 receptor | - |
dc.subject.MESH | Gene Products, gag | - |
dc.subject.MESH | Lectins, C-Type | - |
dc.subject.MESH | Minor Histocompatibility Antigens | - |
dc.subject.MESH | Receptors, Cell Surface | - |
dc.subject.MESH | Recombinant Fusion Proteins | - |
dc.title | Intensified and protective CD4+ T cell immunity in mice with anti-dendritic cell HIV gag fusion antibody vaccine. | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Life Science (의생명과학부) | - |
dc.contributor.googleauthor | Christine Trumpfheller | - |
dc.contributor.googleauthor | Jennifer S. Finke | - |
dc.contributor.googleauthor | Carolina B. López | - |
dc.contributor.googleauthor | Thomas M. Moran | - |
dc.contributor.googleauthor | Bruno Moltedo | - |
dc.contributor.googleauthor | Helena Soares | - |
dc.contributor.googleauthor | Yaoxing Huang | - |
dc.contributor.googleauthor | Sarah J. Schlesinger | - |
dc.contributor.googleauthor | Chae Gyu Park | - |
dc.contributor.googleauthor | Michel C. Nussenzweig | - |
dc.contributor.googleauthor | Angela Granelli-Piperno | - |
dc.contributor.googleauthor | Ralph M. Steinman | - |
dc.identifier.doi | 10.1084/jem.20052005 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01718 | - |
dc.relation.journalcode | J01409 | - |
dc.identifier.eissn | 1540-9538 | - |
dc.identifier.pmid | 16505141 | - |
dc.contributor.alternativeName | Park, Chae Gyu | - |
dc.contributor.affiliatedAuthor | Park, Chae Gyu | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 203 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 607 | - |
dc.citation.endPage | 617 | - |
dc.identifier.bibliographicCitation | JOURNAL OF EXPERIMENTAL MEDICINE, Vol.203(3) : 607-617, 2006 | - |
dc.identifier.rimsid | 39382 | - |
dc.type.rims | ART | - |
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