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Carba Analogs of Cyclic Phosphatidic Acid Are Selective Inhibitors of Autotaxin and Cancer Cell Invasion and Metastasis

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dc.contributor.author고은진-
dc.date.accessioned2015-06-10T13:09:34Z-
dc.date.available2015-06-10T13:09:34Z-
dc.date.issued2006-
dc.identifier.issn0021-9258-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/111118-
dc.description.abstractAutotaxin (ATX, nucleotide pyrophosphate/phosphodiesterase-2, NPP2) is an autocrine motility factor initially characterized from A2058 melanoma cell conditioned medium. ATX is known to contribute to cancer cell survival, growth, and invasion. Recently ATX was shown to be responsible for the lysophospholipase D activity that generates lysophosphatidic acid (LPA). Production of LPA is sufficient to explain the effects of ATX on tumor cells. Cyclic phosphatidic acid (cPA) is a naturally occurring analog of LPA in which the sn-2 hydroxy group forms a 5-membered ring with the sn-3 phosphate. Cellular responses to cPA generally oppose those of LPA despite activation of apparently overlapping receptor populations, suggesting that cPA also activates cellular targets distinct from LPA receptors. cPA has previously been shown to inhibit tumor cell invasion in vitro and cancer cell metastasis in vivo. However, the mechanism governing this effect remains unresolved. Here we show that 3-carba analogs of cPA lack significant agonist activity at LPA receptors yet are potent inhibitors of ATX activity, LPA production, and A2058 melanoma cell invasion in vitro and B16F10 melanoma cell metastasis in vivo.-
dc.description.statementOfResponsibilityopen-
dc.format.extent22786~22793-
dc.relation.isPartOfJOURNAL OF BIOLOGICAL CHEMISTRY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAntineoplastic Agents/pharmacology*-
dc.subject.MESHCell Line, Tumor-
dc.subject.MESHCulture Media, Conditioned-
dc.subject.MESHHumans-
dc.subject.MESHLipid Metabolism-
dc.subject.MESHLysophospholipids/pharmacology-
dc.subject.MESHMelanoma/metabolism-
dc.subject.MESHMultienzyme Complexes/chemistry*-
dc.subject.MESHNeoplasm Invasiveness-
dc.subject.MESHNeoplasm Metastasis-
dc.subject.MESHPhosphatidic Acids/chemistry*-
dc.subject.MESHPhosphodiesterase I/chemistry*-
dc.subject.MESHPhosphoric Diester Hydrolases-
dc.subject.MESHPyrophosphatases/chemistry*-
dc.subject.MESHRecombinant Proteins/chemistry-
dc.subject.MESHSpectrometry, Fluorescence-
dc.titleCarba Analogs of Cyclic Phosphatidic Acid Are Selective Inhibitors of Autotaxin and Cancer Cell Invasion and Metastasis-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Biochemistry & Molecular Biology (생화학,분자생물학)-
dc.contributor.googleauthorDaniel L. Baker-
dc.contributor.googleauthorYuko Fujiwara-
dc.contributor.googleauthorKathryn R. Pigg-
dc.contributor.googleauthorRyoko Tsukahara-
dc.contributor.googleauthorSusumu Kobayashi-
dc.contributor.googleauthorHiromu Murofushi-
dc.contributor.googleauthorAyako Uchiyama-
dc.contributor.googleauthorKimiko Murakami-Murofushi-
dc.contributor.googleauthorEunjin Koh-
dc.contributor.googleauthorRussell W. Bandle-
dc.contributor.googleauthorHoe-Sup Byun-
dc.contributor.googleauthorRobert Bittman-
dc.contributor.googleauthorDominic Fan-
dc.contributor.googleauthorMandi Murph-
dc.contributor.googleauthorGordon B. Mills-
dc.contributor.googleauthorGabor Tigyi-
dc.identifier.doi10.1074/jbc.M512486200-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00139-
dc.relation.journalcodeJ01258-
dc.identifier.eissn1083-351X-
dc.identifier.pmid16782709-
dc.contributor.alternativeNameKoh, Eun Jin-
dc.contributor.affiliatedAuthorKoh, Eun Jin-
dc.rights.accessRightsfree-
dc.citation.volume281-
dc.citation.number32-
dc.citation.startPage22786-
dc.citation.endPage22793-
dc.identifier.bibliographicCitationJOURNAL OF BIOLOGICAL CHEMISTRY, Vol.281(32) : 22786-22793, 2006-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Biochemistry and Molecular Biology (생화학-분자생물학교실) > 1. Journal Papers

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