Cited 15 times in
Emergence of CTX-M-12 extended-spectrum β-lactamase-producing Escherichia coli in Korea
DC Field | Value | Language |
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dc.contributor.author | 배일권 | - |
dc.contributor.author | 정석훈 | - |
dc.date.accessioned | 2015-06-10T13:09:20Z | - |
dc.date.available | 2015-06-10T13:09:20Z | - |
dc.date.issued | 2006 | - |
dc.identifier.issn | 0305-7453 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/111111 | - |
dc.description.abstract | OBJECTIVES: To characterize CTX-M-12 extended-spectrum beta-lactamase (ESBL) produced by clinical Escherichia coli isolates and to investigate its genetic environment. METHODS: Antimicrobial susceptibilities were determined by disc diffusion and agar dilution methods, and the double-disc synergy test was carried out. Detection of genes encoding class A beta-lactamases was performed by PCR amplification, and the genetic environments of the bla(CTX-M-12) genes were investigated by PCR and sequencing of the regions surrounding the genes. Kinetic parameters were determined from purified CTX-M-12. RESULTS: Sequence data for the CTX-M-1 cluster from three clinical E. coli isolates indicated the presence of CTX-M-12. An ISEcp1 insertion sequence was located 49 bp upstream of bla(CTX-M-12) in all three E. coli isolates. CTX-M-12 had a more potent hydrolytic activity against cefotaxime than against ceftazidime and was encoded on a self-transferable approximately 18 kbp plasmid. CONCLUSIONS: This work shows that CTX-M-12, which confers high-level resistance to cefotaxime but not to ceftazidime, has emerged in Korea. The bla(CTX-M-12) gene was associated with an upstream ISEcp1 insertion sequence. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 1257~1259 | - |
dc.relation.isPartOf | JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Anti-Bacterial Agents/metabolism | - |
dc.subject.MESH | Cefotaxime/metabolism | - |
dc.subject.MESH | Ceftazidime/metabolism | - |
dc.subject.MESH | DNA Transposable Elements | - |
dc.subject.MESH | DNA, Bacterial/chemistry | - |
dc.subject.MESH | DNA, Bacterial/genetics | - |
dc.subject.MESH | Escherichia coli/drug effects* | - |
dc.subject.MESH | Escherichia coli/enzymology* | - |
dc.subject.MESH | Escherichia coli/genetics | - |
dc.subject.MESH | Escherichia coli/isolation & purification | - |
dc.subject.MESH | Escherichia coli Infections/microbiology* | - |
dc.subject.MESH | Escherichia coli Proteins/biosynthesis | - |
dc.subject.MESH | Escherichia coli Proteins/genetics | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Kinetics | - |
dc.subject.MESH | Korea | - |
dc.subject.MESH | Microbial Sensitivity Tests | - |
dc.subject.MESH | Molecular Sequence Data | - |
dc.subject.MESH | Plasmids/genetics | - |
dc.subject.MESH | Polymerase Chain Reaction | - |
dc.subject.MESH | Sequence Analysis, DNA | - |
dc.subject.MESH | Substrate Specificity | - |
dc.subject.MESH | beta-Lactamases/biosynthesis* | - |
dc.subject.MESH | beta-Lactamases/genetics | - |
dc.subject.MESH | beta-Lactamases/isolation & purification | - |
dc.subject.MESH | beta-Lactamases/metabolism | - |
dc.title | Emergence of CTX-M-12 extended-spectrum β-lactamase-producing Escherichia coli in Korea | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Laboratory Medicine (진단검사의학) | - |
dc.contributor.googleauthor | Il Kwon Bae | - |
dc.contributor.googleauthor | You-Nae Lee | - |
dc.contributor.googleauthor | Hyun Yong Hwang | - |
dc.contributor.googleauthor | Seok Hoon Jeong | - |
dc.contributor.googleauthor | Su Jin Lee | - |
dc.contributor.googleauthor | Hyo-Sun Kwak | - |
dc.contributor.googleauthor | Wonkeun Song | - |
dc.contributor.googleauthor | Hyoung Jin Kim | - |
dc.contributor.googleauthor | Hasik Youn | - |
dc.identifier.doi | 10.1093/jac/dkl397 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01802 | - |
dc.contributor.localId | A03619 | - |
dc.relation.journalcode | J01237 | - |
dc.identifier.eissn | 1460-2091 | - |
dc.identifier.pmid | 17003059 | - |
dc.subject.keyword | ISEcp1 | - |
dc.subject.keyword | horizontal transfer | - |
dc.subject.keyword | ERIC-PCR | - |
dc.contributor.alternativeName | Bae, Il Kwon | - |
dc.contributor.alternativeName | Jeong, Seok Hoon | - |
dc.contributor.affiliatedAuthor | Bae, Il Kwon | - |
dc.contributor.affiliatedAuthor | Jeong, Seok Hoon | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 58 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 1257 | - |
dc.citation.endPage | 1259 | - |
dc.identifier.bibliographicCitation | JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, Vol.58(6) : 1257-1259, 2006 | - |
dc.identifier.rimsid | 39377 | - |
dc.type.rims | ART | - |
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