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류마티스관절염과 골관절염 환자에 대한 쎄레콕시브의 유효성과 안전성

Other Titles
 Multicenter Study in Efficacy and Safety of Celecoxib in Patients with Rheumatoid Arthritis and Osteoarthritis 
 성상석  ;  박용범  ;  엄완식  ;  이지수  ;  지종대  ;  배상철 
 Journal of the Korean Rheumatism Association (대한류마티스학회지), Vol.13(3) : 209-217, 2006 
Journal Title
 Journal of the Korean Rheumatism Association (대한류마티스학회지) 
Issue Date
Celecoxib ; Efficacy ; Safety ; HRQoL
Objective: The aim of this study was to define the efficacy and safety of celecoxib in Korean patients with rheumatoid arthritis and osteoarthritis. In addition, the impact of gastrointestinal symptom severity on health related quality of life (HRQoL) was measured before and after the treatment with celecoxib. Methods: Three hundred seventy nine patients with rheumatoid arthritis (n=175) and osteoarthritis (n=204) were enrolled from 25 centers from May 2004 to December 2004. After treatment of celecoxib for 4 weeks, efficacy was determined by physician`s global assessment and EQ-5D. Severity of gastrointestinal (GI) symptom was assessed by visual analogue scale. Results: Treatment made improvement in 263 patients (69.4%), but 108 patients (28.5%) didn`t show change in their symptom and 8 patients (2.1%) were aggravated after treatment. Mean change was 0.129±0.3 in EQ-5D utility score (p<0.05), 11.8±17.8 in VAS in EQ-5D (p<0.05) and -7.9±19.6 in GI symptom severity (p<0.05). Blood pressure was not elevated after treatment and there was no cardiovascular adverse event. Gastrointestinal symptom improvement correlates with improvement in VAS (r=0.2, p<0.01). Conclusion: Celecoxib is not only effective in patients with rheumatoid arthritis and osteoarthritis but also helpful in reducing GI symptom.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Park, Yong Beom(박용범)
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