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척수손상 흰쥐에서 방광 내 전기자극치료의 효과 및 기전

Other Titles
 The Effect and Mechanism of Intravesical Electrical Stimulation in Spinal Cord Injured Rats 
Authors
 전형진  ;  김매화  ;  고혜경  ;  홍창희  ;  김장환  ;  한상원 
Citation
 KOREAN JOURNAL OF UROLOGY, Vol.47(3) : 303-309, 2006 
Journal Title
 KOREAN JOURNAL OF UROLOGY 
ISSN
 0494-4747 
Issue Date
2006
Keywords
Electrical stimulation ; c-fos ; Spinal cord injuries ; Rats
Abstract
Purpose: The objective of this study was to evaluate whether the effect on afferent c-fiber activity is the underlying mechanism of intravesical electrical stimulation (IVES) in spinal cord injured rats. Materials and Methods: Thirty five female Sprague-Dawley rats weighting 200-300g each were divided into the normal and spinalized groups. For the spinalized rats, we observed the c-fos expression, and we compared this in the non-IVES group with that in the IVES group. Cystometrograms were performed for all the groups via a suprapubic catheter. Results: After performing IVES in the normal and spinalized rats, the abnormal increases of the intercontraction interval (ICI) and the voiding pressure (VP) were reduced close to the normal range. In the spinalized rats, the number of c-fos positive cells in the dorsal commissure (DCM) decreased in the group that had IVES performed when compared with the non-IVES group. Conclusions: The IVES reduced the c-fos gene expression in the L6-S1 spinal cord segment and also the bladder hyperreflexia in the spinalized rats through the inhibition of afferent c-fiber activity, in addition to affecting the Aδ mechanoreceptors.
Files in This Item:
T200603821.pdf Download
DOI
10.4111/kju.2006.47.3.303
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Urology (비뇨의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Jang Hwan(김장환) ORCID logo https://orcid.org/0000-0002-9056-7072
Han, Sang Won(한상원) ORCID logo https://orcid.org/0000-0003-0941-1300
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/110914
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