Cited 3 times in
Low-Dose Aspirin Affects the Clinicopathological Features of Gastric Cancer
DC Field | Value | Language |
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dc.contributor.author | 이용찬 | - |
dc.contributor.author | 정재복 | - |
dc.contributor.author | 황혜진 | - |
dc.contributor.author | 김지현 | - |
dc.contributor.author | 윤영훈 | - |
dc.date.accessioned | 2015-06-10T13:00:55Z | - |
dc.date.available | 2015-06-10T13:00:55Z | - |
dc.date.issued | 2006 | - |
dc.identifier.issn | 0012-2823 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/110852 | - |
dc.description.abstract | Background/Aims: There have been investigations on the chemopreventive effect of nonsteroidal anti-inflammatory drugs (NSAIDs) in gastric cancer and also on the association between cyclo-oxygenase 2 expression and the clinicopathological features of gastric cancer. However, it is not yet clear whether the cardioprotective properties of low-dose aspirin could affect the biological behavior of gastric cancer. This study was aimed at investigating the association between the use of low-dose aspirin and clinicopathological features of gastric cancer in human. Method: A case-control study was performed retrospectively by comparing the clinicopathological parameters between two groups of gastric cancers, 47 (30.5%) low-dose aspirin users and 107 (69.5%) non-aspirin users who were diagnosed and underwent operation for gastric cancers. Results: The gastric cancers of aspirin user group showed favorable clinicopathological features, such as earlier tumor stage (overall stage, T and N stage: p < 0.001, <0.001, and 0.002, respectively), smaller size (p = 0.03), and intestinal type rather than diffuse type (p = 0.004). But these differences were significant only in non-cardiac cancer while cardiac cancer patients showed no significant association with low-dose aspirin usage (overall stage, T stage, N stage, tumor size, and histological type: p <0.001, <0.001, 0.003, 0.035, and 0.004, respectively, by Cochran-Mantel-Haenszel statistics). Conclusion: The use of low-dose aspirin might affect the clinicopathological features in gastric cancers, and possibly have a favorable protective effect on the progression of gastric cancer in a subset of non-cardiac gastric cancer patients. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 54~59 | - |
dc.relation.isPartOf | DIGESTION | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Aspirin/administration & dosage* | - |
dc.subject.MESH | Case-Control Studies | - |
dc.subject.MESH | Chi-Square Distribution | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Neoplasm Staging | - |
dc.subject.MESH | Stomach Neoplasms/pathology* | - |
dc.title | Low-Dose Aspirin Affects the Clinicopathological Features of Gastric Cancer | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Hwang H.J. | - |
dc.contributor.googleauthor | Youn Y.H. | - |
dc.contributor.googleauthor | Kim J.-H. | - |
dc.contributor.googleauthor | Chung J.B. | - |
dc.contributor.googleauthor | Lee Y.C. | - |
dc.identifier.doi | 10.1159/000092248 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02988 | - |
dc.contributor.localId | A03706 | - |
dc.contributor.localId | A04496 | - |
dc.contributor.localId | A02583 | - |
dc.contributor.localId | A00996 | - |
dc.relation.journalcode | J00734 | - |
dc.identifier.eissn | 1421-9867 | - |
dc.identifier.pmid | 16554658 | - |
dc.identifier.url | http://www.karger.com/Article/FullText/92248 | - |
dc.subject.keyword | Aspirin | - |
dc.subject.keyword | Gastric cancer | - |
dc.subject.keyword | Chemoprevention | - |
dc.contributor.alternativeName | Lee, Yong Chan | - |
dc.contributor.alternativeName | Chung, Jae Bock | - |
dc.contributor.alternativeName | Hwang, Hye Jin | - |
dc.contributor.alternativeName | Kim, Ji Hyun | - |
dc.contributor.alternativeName | Youn, Young Hoon | - |
dc.contributor.affiliatedAuthor | Lee, Yong Chan | - |
dc.contributor.affiliatedAuthor | Chung, Jae Bock | - |
dc.contributor.affiliatedAuthor | Hwang, Hye Jin | - |
dc.contributor.affiliatedAuthor | Youn, Young Hoon | - |
dc.contributor.affiliatedAuthor | Kim, Ji Hyun | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 73 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 54 | - |
dc.citation.endPage | 59 | - |
dc.identifier.bibliographicCitation | DIGESTION, Vol.73(1) : 54-59, 2006 | - |
dc.identifier.rimsid | 54485 | - |
dc.type.rims | ART | - |
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