Cited 25 times in

Transcriptional Regulation of Glucose Sensors in Pancreatic β Cells and Liver

DC Field Value Language
dc.contributor.author김하일-
dc.contributor.author안용호-
dc.contributor.author임승순-
dc.date.accessioned2015-06-10T12:59:54Z-
dc.date.available2015-06-10T12:59:54Z-
dc.date.issued2006-
dc.identifier.issn1573-3998-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/110824-
dc.description.abstractDerangement of glucose metabolism is a key feature of T2DM, with the liver and pancreatic β-cells playing a key role in glucose homeostasis. In the postprandial state, glucose is transported into hepatocytes and either metabolized to fatty acids or CO2, or stored as glycogen. Glucose also acts as a key signal in pancreatic β-cells for regulating insulin secretion. Because GLUT2 and GK expressed in liver and β-cells are responsible for sensing glucose levels in the blood, studies on the regulation of these biomolecules are important in understanding glucose homeostasis in vivo. These molecules are known to be regulated either transcriptionally or post-transcriptionally, and recent studies on the structure and function of promoters of these genes have revealed the involvement of various transcriptional factors in their regulation. Here, we review recent progress in elucidating the transcriptional regulation of glucose sensors in the liver and pancreatic β-cells and the relevance to T2DM.-
dc.description.statementOfResponsibilityopen-
dc.format.extent11~18-
dc.relation.isPartOfCURRENT DIABETES REVIEWS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHChromosome Mapping-
dc.subject.MESHChromosomes, Human, Pair 3-
dc.subject.MESHDiabetes Mellitus, Type 2/physiopathology*-
dc.subject.MESHGlucokinase/genetics-
dc.subject.MESHGlucose Transporter Type 2/genetics*-
dc.subject.MESHHumans-
dc.subject.MESHInsulin/metabolism*-
dc.subject.MESHInsulin Secretion-
dc.subject.MESHInsulin-Secreting Cells/enzymology-
dc.subject.MESHInsulin-Secreting Cells/physiology*-
dc.subject.MESHLiver/physiology*-
dc.subject.MESHPromoter Regions, Genetic-
dc.subject.MESHTranscription, Genetic*-
dc.titleTranscriptional Regulation of Glucose Sensors in Pancreatic β Cells and Liver-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Biochemistry & Molecular Biology (생화학,분자생물학)-
dc.contributor.googleauthorSeung-Soon Im-
dc.contributor.googleauthorSo-Youn Kim-
dc.contributor.googleauthorHa-il Kim-
dc.contributor.googleauthorYong-Ho Ahn-
dc.identifier.doi10.2174/157339906775473581-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01092-
dc.contributor.localIdA02249-
dc.contributor.localIdA03376-
dc.relation.journalcodeJ00663-
dc.identifier.eissn1875-6417-
dc.identifier.pmid18220613-
dc.identifier.urlhttp://www.eurekaselect.com/55108/article-
dc.subject.keywordType 2 glucose transporter isoform (GLUT2)-
dc.subject.keywordGlucokinase (GK)-
dc.subject.keywordGlucose sensor-
dc.subject.keywordTranscription-
dc.subject.keywordLiver-
dc.subject.keywordPancreatic βcells-
dc.contributor.alternativeNameKim, Ha Il-
dc.contributor.alternativeNameAhn, Yong Ho-
dc.contributor.alternativeNameIm, Seung Soon-
dc.contributor.affiliatedAuthorKim, Ha Il-
dc.contributor.affiliatedAuthorAhn, Yong Ho-
dc.contributor.affiliatedAuthorIm, Seung Soon-
dc.rights.accessRightsnot free-
dc.citation.volume2-
dc.citation.number1-
dc.citation.startPage11-
dc.citation.endPage18-
dc.identifier.bibliographicCitationCURRENT DIABETES REVIEWS, Vol.2(1) : 11-18, 2006-
dc.identifier.rimsid54466-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Biochemistry and Molecular Biology (생화학-분자생물학교실) > 1. Journal Papers

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