2 258

Cited 22 times in

Transcriptional Regulation of Glucose Sensors in Pancreatic β Cells and Liver

Authors
 Seung-Soon Im  ;  So-Youn Kim  ;  Ha-il Kim  ;  Yong-Ho Ahn 
Citation
 CURRENT DIABETES REVIEWS, Vol.2(1) : 11-18, 2006 
Journal Title
 CURRENT DIABETES REVIEWS 
ISSN
 1573-3998 
Issue Date
2006
MeSH
Chromosome Mapping ; Chromosomes, Human, Pair 3 ; Diabetes Mellitus, Type 2/physiopathology* ; Glucokinase/genetics ; Glucose Transporter Type 2/genetics* ; Humans ; Insulin/metabolism* ; Insulin Secretion ; Insulin-Secreting Cells/enzymology ; Insulin-Secreting Cells/physiology* ; Liver/physiology* ; Promoter Regions, Genetic ; Transcription, Genetic*
Keywords
Type 2 glucose transporter isoform (GLUT2) ; Glucokinase (GK) ; Glucose sensor ; Transcription ; Liver ; Pancreatic βcells
Abstract
Derangement of glucose metabolism is a key feature of T2DM, with the liver and pancreatic β-cells playing a key role in glucose homeostasis. In the postprandial state, glucose is transported into hepatocytes and either metabolized to fatty acids or CO2, or stored as glycogen. Glucose also acts as a key signal in pancreatic β-cells for regulating insulin secretion. Because GLUT2 and GK expressed in liver and β-cells are responsible for sensing glucose levels in the blood, studies on the regulation of these biomolecules are important in understanding glucose homeostasis in vivo. These molecules are known to be regulated either transcriptionally or post-transcriptionally, and recent studies on the structure and function of promoters of these genes have revealed the involvement of various transcriptional factors in their regulation. Here, we review recent progress in elucidating the transcriptional regulation of glucose sensors in the liver and pancreatic β-cells and the relevance to T2DM.
Full Text
http://www.eurekaselect.com/55108/article
DOI
10.2174/157339906775473581
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Biochemistry and Molecular Biology (생화학-분자생물학교실) > 1. Journal Papers
Yonsei Authors
Kim, Ha Il(김하일)
Ahn, Yong Ho(안용호) ORCID logo https://orcid.org/0000-0002-4133-0757
Im, Seung Soon(임승순)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/110824
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse