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Magnetic PECA nanoparticles as drug carriers for targeted delivery: Synthesis and release characteristics

Authors
 J. Yang  ;  H. Lee  ;  W. Hyung  ;  S.-B. Park  ;  S. Haam 
Citation
 JOURNAL OF MICROENCAPSULATION, Vol.23(2) : 203-212, 2006 
Journal Title
JOURNAL OF MICROENCAPSULATION
ISSN
 0265-2048 
Issue Date
2006
MeSH
Cyanoacrylates/administration & dosage* ; Cyanoacrylates/chemistry ; Drug Carriers* ; Drug Delivery Systems* ; Magnetics* ; Microscopy, Electron, Scanning ; Microscopy, Electron, Transmission ; Nanoparticles*/ultrastructure ; Nanotechnology/methods ; Particle Size ; Polymers/administration & dosage ; Polymers/chemistry ; Spectroscopy, Fourier Transform Infrared
Abstract
Magnetic poly(ethyl-2-cyanoacrylate) (PECA) nanoparticles containing anti-cancer drugs (Cisplatin and Gemcitabine) were prepared by inter-facial polymerization. The spherical nanoparticles (d = 250 ± 15 nm) with smooth surfaces and moderately uniform size distributions were obtained. The amount of magnetite encapsulated inside the polymer matrix was increased up to 14.26% (w/w) by controlling the initial weight ratio of monomer/magnetite. It was found that the amount of Cisplatin encapsulated in the magnetic nanoparticle is much higher than that of Gemcitabine because Cisplatin (hydrophobic) is highly soluble in the oil phase and encapsulated easier inside nanoparticles compared to Gemcitabine (hydrophilic). The presence of magnetite and its super-paramagnetic characteristic were confirmed by FTIR spectra and VSM. In-vitro experiments of drug release and magnetic mobility under external magnetic field demonstrated that magnetic poly(ethyl-2-cyanoacrylate) (PECA) nanoparticles can be a highly versatile magnetic drug carrier with sustained release behaviour and sufficient magnetic susceptibility.
Full Text
http://informahealthcare.com/doi/abs/10.1080/02652040500435444%20
DOI
10.1080/02652040500435444
Appears in Collections:
1. College of Medicine (의과대학) > Research Institute (부설연구소) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Yang, Jae Moon(양재문) ORCID logo https://orcid.org/0000-0001-7365-0395
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/110821
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