Cited 205 times in
The plasma alpha-synuclein levels in patients with Parkinson’s disease and multiple system atrophy
DC Field | Value | Language |
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dc.contributor.author | 이필휴 | - |
dc.date.accessioned | 2015-06-10T12:59:27Z | - |
dc.date.available | 2015-06-10T12:59:27Z | - |
dc.date.issued | 2006 | - |
dc.identifier.issn | 0300-9564 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/110811 | - |
dc.description.abstract | α-Synuclein, a synaptic protein of unknown function, is a major component of Lewy bodies and may play a role in the pathophysiological process of Parkinson’s disease (PD). In this study, we measured the plasma α-synuclein levels in 105 patients with PD, 38 patients with multiple system atrophy (MSA), and 51 age-matched controls. The α-synuclein level was significantly elevated in patients with PD (79.9 ± 4.0 pg/ml, p < 0.001) and in those with MSA (78.1 ± 3.5 pg/ml, p = 0.019) compared with the level in controls (76.1 ± 3.9 pg/ml). The α-synuclein level was higher in patients with PD than in those with MSA (79.9 ± 4.0 vs 78.1 ± 3.5, p = 0.016). Our study demonstrated that the α-synuclein level in plasma is elevated in patients with PD and MSA. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 1435~1439 | - |
dc.relation.isPartOf | JOURNAL OF NEURAL TRANSMISSION | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Enzyme-Linked Immunosorbent Assay | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Multiple System Atrophy/blood* | - |
dc.subject.MESH | Parkinson Disease/blood* | - |
dc.subject.MESH | alpha-Synuclein/blood* | - |
dc.title | The plasma alpha-synuclein levels in patients with Parkinson’s disease and multiple system atrophy | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Neurology (신경과학) | - |
dc.contributor.googleauthor | P. H. Lee | - |
dc.contributor.googleauthor | G. Lee | - |
dc.contributor.googleauthor | H. J. Park | - |
dc.contributor.googleauthor | O. Y. Bang | - |
dc.contributor.googleauthor | I. S. Joo | - |
dc.contributor.googleauthor | K. Huh | - |
dc.identifier.doi | 10.1007/s00702-005-0427-9 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A03270 | - |
dc.relation.journalcode | J01619 | - |
dc.identifier.eissn | 1435-1463 | - |
dc.identifier.pmid | 16465458 | - |
dc.identifier.url | http://link.springer.com/article/10.1007%2Fs00702-005-0427-9 | - |
dc.subject.keyword | α-Synuclein | - |
dc.subject.keyword | Parkinson’s disease | - |
dc.subject.keyword | multiple system atrophy | - |
dc.contributor.alternativeName | Lee, Phil Hyu | - |
dc.contributor.affiliatedAuthor | Lee, Phil Hyu | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 113 | - |
dc.citation.number | 10 | - |
dc.citation.startPage | 1435 | - |
dc.citation.endPage | 1439 | - |
dc.identifier.bibliographicCitation | JOURNAL OF NEURAL TRANSMISSION, Vol.113(10) : 1435-1439, 2006 | - |
dc.identifier.rimsid | 54457 | - |
dc.type.rims | ART | - |
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