Cited 17 times in
Plasma adiponectin is related to other cardiovascular risk factors in nondiabetic Korean men with CAD, independent of adiposity and cigarette smoking: Cross-sectional analysis
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 장양수 | - |
dc.date.accessioned | 2015-06-10T12:58:32Z | - |
dc.date.available | 2015-06-10T12:58:32Z | - |
dc.date.issued | 2006 | - |
dc.identifier.issn | 0009-8981 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/110784 | - |
dc.description.abstract | BACKGROUND: Circulating adiponectins have multiple protective roles as anti-diabetic, anti-atherosclerotic, and anti-inflammatory factors. We examined the relationship between plasma adiponectin concentration and other cardiovascular risk in nondiabetic coronary artery disease (CAD) men and the relationship can be maintained even after adjusted for major environmental factors that contribute to adiponectin concentrations. METHODS: Nondiabetic CAD men (n=613) were 31-70 y and had body mass index (BMI) of 18.5-29.9 kg/m2. RESULTS: Circulating adiponectins positively correlated with age and negatively with BMI, waist circumference and % body fat (p-values of all <0.001). Plasma adiponectin concentrations were higher in never-smokers (5.07+/-0.30 microg/ml) than current (4.15+/-0.12 microg/ml) and ex-smokers (3.75+/-0.20 microg/ml) both before and after adjusted for age and adiposity (p=0.002 and p=0.008, respectively), however they were not significantly different according to alcohol drinking status. After adjusted for age, adiposity and cigarette smoking, plasma adiponectin still have positive correlations with HDL cholesterol, apolipoprotein AI and LDL particle size, and inversely with fasting triglyceride, atherogenic index, insulin resistance and C-reactive protein (CRP). However there was no significant relationships between adiponectin and apolipoprotein B, total cholesterol or LDL cholesterol. In subset analysis by tertile adiponectin concentrations (lowest: <2.92, moderate: 2.92<or=adiponectin<4.75, highest: >or=4.75 microg/ml), 'moderate' and 'highest' adiponectin groups had lower triglyceride (p<0.001), lower atherogenic index (p=0.001), lower fasting insulin (p=0.004), lower insulin resistance (p=0.001), lower CRP (p=0.001), higher HDL cholesterol (p<0.001), higher apolipoprotein AI (p=0.005) and higher LDL particle size (p<0.001) as compared with 'lowest' adiponectin group when adjusted for age, adiposity and cigarette smoking. Platelets were lower in 'highest' adiponectin groups as compared with 'lowest' and 'moderate' adiponectin group after the adjustment. However, there was no significant difference in total cholesterol (p=0.145), LDL cholesterol (p=0.145), apolipoprotein B (p=0.222) and fasting glucose (p=0.157). CONCLUSION: An increase of adiponectin concentrations or the maintenance of higher concentration may be negatively associated with cardiovascular risk factors in nondiabetic CAD male patients, independent of adiposity and smoking status. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 63~71 | - |
dc.relation.isPartOf | CLINICA CHIMICA ACTA | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adiponectin/blood* | - |
dc.subject.MESH | Adiposity/physiology | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Alcohol Drinking/adverse effects | - |
dc.subject.MESH | Asian Continental Ancestry Group | - |
dc.subject.MESH | Biomarkers | - |
dc.subject.MESH | Coronary Artery Disease/blood* | - |
dc.subject.MESH | Coronary Artery Disease/epidemiology* | - |
dc.subject.MESH | Cross-Sectional Studies | - |
dc.subject.MESH | Diabetes Mellitus | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Insulin Resistance | - |
dc.subject.MESH | Korea/epidemiology | - |
dc.subject.MESH | Lipid Metabolism | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Risk Factors | - |
dc.subject.MESH | Smoking/adverse effects | - |
dc.title | Plasma adiponectin is related to other cardiovascular risk factors in nondiabetic Korean men with CAD, independent of adiposity and cigarette smoking: Cross-sectional analysis | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Oh Yoen Kim | - |
dc.contributor.googleauthor | Soo Jeong Koh | - |
dc.contributor.googleauthor | Yangsoo Jang | - |
dc.contributor.googleauthor | Jey Sook Chae | - |
dc.contributor.googleauthor | Ji Young Kim | - |
dc.contributor.googleauthor | Hyae Jin Kim | - |
dc.contributor.googleauthor | Hongkeun Cho | - |
dc.contributor.googleauthor | Jong Ho Lee | - |
dc.identifier.doi | 10.1016/j.cca.2006.01.021 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A03448 | - |
dc.relation.journalcode | J00543 | - |
dc.identifier.eissn | 1873-3492 | - |
dc.identifier.pmid | 16530178 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0009898106000799 | - |
dc.subject.keyword | Adiponectin | - |
dc.subject.keyword | Coronary artery disease | - |
dc.subject.keyword | Cardiovascular risk adiposity | - |
dc.subject.keyword | Cigarette smoking | - |
dc.contributor.alternativeName | Jang, Yang Soo | - |
dc.contributor.affiliatedAuthor | Jang, Yang Soo | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 370 | - |
dc.citation.number | 1-2 | - |
dc.citation.startPage | 63 | - |
dc.citation.endPage | 71 | - |
dc.identifier.bibliographicCitation | CLINICA CHIMICA ACTA, Vol.370(1-2) : 63-71, 2006 | - |
dc.identifier.rimsid | 54431 | - |
dc.type.rims | ART | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.