Cited 82 times in
The Effect of Modifiable Risk Factors on Pancreatic Cancer Mortality in Populations of the Asia-Pacific Region
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 지선하 | - |
dc.date.accessioned | 2015-06-10T12:55:01Z | - |
dc.date.available | 2015-06-10T12:55:01Z | - |
dc.date.issued | 2006 | - |
dc.identifier.issn | 1055-9965 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/110680 | - |
dc.description.abstract | BACKGROUND: Pancreatic cancer accounts for about 220,000 deaths each year. Known risk factors are smoking and type 2 diabetes. It remains to be seen whether these risk factors are equally important in Asia and whether other modifiable risk factors have important associations with pancreatic cancer. METHODS: An individual participant data analysis of 30 cohort studies was carried out, involving 420,310 Asian participants (33% female) and 99,333 from Australia/New Zealand (45% female). Cox proportional hazard models, stratified by study and sex and adjusted for age, were used to quantify risk factors for death from pancreatic cancer. RESULTS: During 3,558,733 person-years of follow-up, there were 324 deaths from pancreatic cancer (54% Asia and 33% female). Mortality rates (per 100,000 person-years) from pancreatic cancer were 10 for men and 8 for women. The following are age-adjusted hazard ratios (95% confidence interval) for death from pancreatic cancer: for current smoking, 1.61 (1.12-2.32); for diabetes, 1.76 (1.15-2.69); for a 2-cm increase in waist circumference, 1.08 (1.02-1.14). All three relationships remained significant (P < 0.05) after adjustment for other risk factors. There was no evidence of heterogeneity in the strength of these associations between either cohorts from Asia and Australia/New Zealand or between the sexes. In men, the combination of cigarette smoking and diabetes more than doubled the likelihood of pancreatic cancer (2.47; 95% confidence interval, 1.17-5.21) in both regions. CONCLUSIONS: Smoking, obesity, and diabetes are important and are potentially modifiable risk factors for pancreatic cancer in populations of the Asia-Pacific region. Activities to prevent them can be expected to lead to a major reduction in the number of deaths from this cancer, particularly in Asia with its enormous population. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 2435~2440 | - |
dc.relation.isPartOf | CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Asia/epidemiology | - |
dc.subject.MESH | Australia/epidemiology | - |
dc.subject.MESH | Cohort Studies | - |
dc.subject.MESH | Diabetes Complications/epidemiology | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | New Zealand/epidemiology | - |
dc.subject.MESH | Obesity/epidemiology | - |
dc.subject.MESH | Pancreatic Neoplasms/epidemiology | - |
dc.subject.MESH | Pancreatic Neoplasms/etiology* | - |
dc.subject.MESH | Pancreatic Neoplasms/mortality | - |
dc.subject.MESH | Risk Factors | - |
dc.subject.MESH | Smoking/epidemiology | - |
dc.title | The Effect of Modifiable Risk Factors on Pancreatic Cancer Mortality in Populations of the Asia-Pacific Region | - |
dc.type | Article | - |
dc.contributor.college | Graduate School of Public Health (보건대학원) | - |
dc.contributor.department | Graduate School of Public Health (보건대학원) | - |
dc.contributor.googleauthor | Alireza Ansary-Moghaddam | - |
dc.contributor.googleauthor | Rachel Huxley | - |
dc.contributor.googleauthor | Federica Barzi | - |
dc.contributor.googleauthor | Carlene Lawes | - |
dc.contributor.googleauthor | Takayoshi Ohkubo | - |
dc.contributor.googleauthor | Xianghua Fang | - |
dc.contributor.googleauthor | Sun Ha Jee | - |
dc.contributor.googleauthor | Mark Woodward | - |
dc.identifier.doi | 10.1158/1055-9965.EPI-06-0368 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A03965 | - |
dc.relation.journalcode | J00441 | - |
dc.identifier.eissn | 1538-7755 | - |
dc.identifier.pmid | 17164367 | - |
dc.contributor.alternativeName | Jee, Sun Ha | - |
dc.contributor.affiliatedAuthor | Jee, Sun Ha | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 15 | - |
dc.citation.number | 12 | - |
dc.citation.startPage | 2435 | - |
dc.citation.endPage | 2440 | - |
dc.identifier.bibliographicCitation | CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, Vol.15(12) : 2435-2440, 2006 | - |
dc.identifier.rimsid | 57541 | - |
dc.type.rims | ART | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.