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The Effect of Modifiable Risk Factors on Pancreatic Cancer Mortality in Populations of the Asia-Pacific Region

Authors
 Alireza Ansary-Moghaddam  ;  Rachel Huxley  ;  Federica Barzi  ;  Carlene Lawes  ;  Takayoshi Ohkubo  ;  Xianghua Fang  ;  Sun Ha Jee  ;  Mark Woodward 
Citation
 CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, Vol.15(12) : 2435-2440, 2006 
Journal Title
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
ISSN
 1055-9965 
Issue Date
2006
MeSH
Asia/epidemiology ; Australia/epidemiology ; Cohort Studies ; Diabetes Complications/epidemiology ; Female ; Humans ; Male ; Middle Aged ; New Zealand/epidemiology ; Obesity/epidemiology ; Pancreatic Neoplasms/epidemiology ; Pancreatic Neoplasms/etiology* ; Pancreatic Neoplasms/mortality ; Risk Factors ; Smoking/epidemiology
Abstract
BACKGROUND: Pancreatic cancer accounts for about 220,000 deaths each year. Known risk factors are smoking and type 2 diabetes. It remains to be seen whether these risk factors are equally important in Asia and whether other modifiable risk factors have important associations with pancreatic cancer.
METHODS: An individual participant data analysis of 30 cohort studies was carried out, involving 420,310 Asian participants (33% female) and 99,333 from Australia/New Zealand (45% female). Cox proportional hazard models, stratified by study and sex and adjusted for age, were used to quantify risk factors for death from pancreatic cancer.
RESULTS: During 3,558,733 person-years of follow-up, there were 324 deaths from pancreatic cancer (54% Asia and 33% female). Mortality rates (per 100,000 person-years) from pancreatic cancer were 10 for men and 8 for women. The following are age-adjusted hazard ratios (95% confidence interval) for death from pancreatic cancer: for current smoking, 1.61 (1.12-2.32); for diabetes, 1.76 (1.15-2.69); for a 2-cm increase in waist circumference, 1.08 (1.02-1.14). All three relationships remained significant (P < 0.05) after adjustment for other risk factors. There was no evidence of heterogeneity in the strength of these associations between either cohorts from Asia and Australia/New Zealand or between the sexes. In men, the combination of cigarette smoking and diabetes more than doubled the likelihood of pancreatic cancer (2.47; 95% confidence interval, 1.17-5.21) in both regions.
CONCLUSIONS: Smoking, obesity, and diabetes are important and are potentially modifiable risk factors for pancreatic cancer in populations of the Asia-Pacific region. Activities to prevent them can be expected to lead to a major reduction in the number of deaths from this cancer, particularly in Asia with its enormous population.
Files in This Item:
T200601664.pdf Download
DOI
10.1158/1055-9965.EPI-06-0368
Appears in Collections:
4. Graduate School of Public Health (보건대학원) > Graduate School of Public Health (보건대학원) > 1. Journal Papers
Yonsei Authors
Jee, Sun Ha(지선하) ORCID logo https://orcid.org/0000-0001-9519-3068
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/110680
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