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방사선치료로 인한 통증 및 암성통증에 대한 듀로제식의 효과: 다기관연구

Other Titles
 Effectiveness of Fentanyl Transdermal Patch (Fentanyl-TTS, Durogegic?) for Radiotherapy Induced Pain and Cancer Pain: Multi-center Trial 
 신성수  ;  허승재  ;  최은경  ;  김종훈  ;  안승도  ;  이상욱  ;  김연실  ;  이규찬  ;  이창걸  ;  노준규  ;  전미선  ;  오영택  ;  김옥배  ;  김진희  ;  김철용  ;  양대식  ;  박우윤  ;  김보경  ;  조흥래  ;  안기정  ;  이종영  ;  윤선민  ;  안용찬  ;  임도훈  ;  박원  ;  강기문  ;  우홍균  ;  신현수  ;  장성순  ;  김은석  ;  나병식  ;  정웅기  ;  안성자  ;  남택근  ;  김용호  ;  송미희  ;  윤상모  ;  계철승  ;  예지원  ;  박석원  ;  김선우 
 Journal of the Korean Society for Therapeutic Radiology and Oncology, Vol.24(4) : 263-271, 2006 
Journal Title
Journal of the Korean Society for Therapeutic Radiology and Oncology(대한방사선종양학회지)
Issue Date
Cancer pain ; Radiotherapy induced pain ; Fentanyl Transdermal Patch
Purpose: To evaluate the effectiveness and safety of fentanyl-TTS in the management of radiotherapy induced acute pain and cancer pain treated with radiotherapy. Materials and Methods: Our study was open labelled prospective phase IV multi-center study. the study population included patients with more 4 numeric rating scale(NRS) score pain although managed with other analgesics or more than 6 NRS score pain without analgesics. Patients divided into two groups; patients with radiotherapy induced pain (Group A) and patients with cancer pain treated with radiotherapy (Group B). All patients received 25 ug/hr of fentanyl transdermal patch. Primary end point was pain relief; second end points were change in patient quality of life, a degree of satisfaction for patients and clinician, side effects. Results: Between March 2005 and June 2005, 312 patients from 26 participating institutes were registered, but 249 patients completed this study. Total number of patients in each group was 185 in Group A, 64 in Group B. Mean age was 60 years and male to female ratio was 76:24. Severe pain NRS score at 2 weeks after the application of fentanyl was decreased from 7.03 to 4.01, p=0.003. There was a significant improvement in insomnia, social functioning, and quality of life. A degree of satisfaction for patients and clinician was very high. The most common reasons of patients’ satisfactions was good pain control. Ninety six patients reported side effect. Nausea was the most common side effect. There was no serious side effect. Conclusion: Fentanyl-TTS was effective in both relieving pain with good tolerability and improving the quality of life for patients with radiotherapy induced acute pain and cancer pain treated with radiotherapy. The satisfaction of the patients and doctors was good. There was no major side effect.
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실) > 1. Journal Papers
Yonsei Authors
Lee, Chang Geol(이창걸) ORCID logo https://orcid.org/0000-0002-8702-881X
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