166 655

Cited 0 times in

혈장사혈과 감마글로브린으로 림프구 교차반응 음성전환 후 시행한 신장이식의 1년 이상 추적결과

DC Field Value Language
dc.contributor.author김명수-
dc.contributor.author김순일-
dc.contributor.author김유선-
dc.contributor.author주동진-
dc.date.accessioned2015-06-10T12:53:02Z-
dc.date.available2015-06-10T12:53:02Z-
dc.date.issued2006-
dc.identifier.issn1298-1711-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/110620-
dc.description.abstractPurpose: Many patients who have an acceptable living-kidney donor do not undergo transplantation because of the presence of antibodies against the donor cells resulting in a positive lymphocyte-crossmatch (LCX). Recently, the combination therapy of plasmapheresis, intravenous gamma-globulin and potent immunosuppression to induce negative conversion of LCX in patients who had positive LCX to their living donors was reported. Our institute gave these patients the combination therapy and reported the results of follow-up done 1~3 years after kidney transplantation. Methods: Eleven patients, who showed positive LCX to their living donors, underwent the conversion trials between January 1, 2002 and March 31, 2004. Combination therapy consisting of plasmapheresis, intravenous gamma globulin injection, tacrolimus, mycophenolate mofetil (MMF) and steroids was used. Plasmapheresis had been done every other day up to 6 times. Kidney transplantations were performed immediately after negative conversion was achieved. Five to ten day-courses of ATG (or OKT3) were used as an induction immunosuppression and tacrolimus, MMF, and steroids as a maintenance immunosuppression. Results: Negative conversions in ten out of eleven patients were achieved. Kidney transplantations in these 10 patients were successfully performed. No hyperacute rejection transpired, although four patients developed acute rejection, whose grafts were all rescued with steroid pulse therapy. Serum creatinine level was 1.57±0.12 ㎎/㎗ (mean±SD) during follow-up periods except for one whose graft was lost to Polyoma virus nephropathy. Conclusion: Nine of the 10 grafts are functioning well for 15~41 months after transplantations. Our results suggest that selected crossmatch positive patients can be transplanted successfully with living donor kidney allograft.-
dc.description.statementOfResponsibilityopen-
dc.formatapplication/pdf-
dc.languageJournal of the Korean Society for Transplantation-
dc.publisherJournal of the Korean Society for Transplantation-
dc.relation.isPartOfJournal of the Korean Society for Transplantation-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.title혈장사혈과 감마글로브린으로 림프구 교차반응 음성전환 후 시행한 신장이식의 1년 이상 추적결과-
dc.title.alternativeThe Result of Renal Allograft which Lymphocyte Crossmatch is Negatively Converted by Pretransplant Plasmapheresis and 4 γ-globulin-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Surgery (외과학)-
dc.contributor.googleauthor주동진-
dc.contributor.googleauthor김명수-
dc.contributor.googleauthor안형준-
dc.contributor.googleauthor주만기-
dc.contributor.googleauthor전경옥-
dc.contributor.googleauthor김현정-
dc.contributor.googleauthor김순일-
dc.contributor.googleauthor김유선-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00649-
dc.contributor.localIdA00785-
dc.contributor.localIdA00424-
dc.relation.journalcodeJ01858-
dc.identifier.eissn2508-2604-
dc.subject.keywordPositive Lymphocyte cross-match-
dc.subject.keywordPlasmapheresis-
dc.subject.keywordIntravenous gamma globulin-
dc.subject.keywordImmunosuppression-
dc.contributor.alternativeNameKim, Myoung Soo-
dc.contributor.alternativeNameKim, Soon Il-
dc.contributor.alternativeNameKim, Yu Seun-
dc.contributor.affiliatedAuthorKim, Soon Il-
dc.contributor.affiliatedAuthorKim, Yu Seun-
dc.contributor.affiliatedAuthorKim, Myoung Soo-
dc.rights.accessRightsnot free-
dc.citation.volume20-
dc.citation.number2-
dc.citation.startPage207-
dc.citation.endPage212-
dc.identifier.bibliographicCitationJournal of the Korean Society for Transplantation, Vol.20(2) : 207-212, 2006-
dc.identifier.rimsid57494-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.