Cited 0 times in
자궁경부암에서 Cdc25A, Cdc25B 및 Cdc25C의 발현
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김영태 | - |
dc.contributor.author | 김재욱 | - |
dc.contributor.author | 김재훈 | - |
dc.contributor.author | 김성훈 | - |
dc.contributor.author | 김세광 | - |
dc.date.accessioned | 2015-06-10T12:41:33Z | - |
dc.date.available | 2015-06-10T12:41:33Z | - |
dc.date.issued | 2006 | - |
dc.identifier.issn | 2287-8572 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/110273 | - |
dc.description.abstract | Objective: This study was undertaken to quantitatively detect Cdc25A, Cdc25B and Cdc25C in cervical carcinoma and determine the relationship between the expression of mRNA and protein of cell division cycle (Cdc)25 phosphatase and various clinicopathologic prognostic factors of cervical carcinoma. Methods: 39 patients diagnosed with cervical carcinoma between February 2000 to March 2005 and 10 patients with benign gynecologic disease were enrolled in this study. A reverse transcriptase-polymerase chain reaction (RT-PCR) and Western blot analysis were used to analyze the expression of Cdc25 phosphatase mRNA and protein in fresh invasive cervical cancer tissue and normal cervix tissue. Results: The mRNA expressions of Cdc25A, Cdc25B and Cdc25C in the cancer tissues were significantly greater than in the control (p=0.02, 0.01, 0.02), respectively. A Western blot analysis yielded same results (p=0.01, 0.02, 0.01). There were also significant relationships between the age and the Cdc25B mRNA expression (p=0.03), between the cell type and the Cdc25C mRNA expression (p=0.04). However, other clinicopathologic prognostic factors including stage, subtype, SCC Ag level, DNA flow cytometry, lymph node metastasis, lymphovascular space invasion and HPV positivity were not statistically significant. Conclusion: Our results show that Cdc25A, Cdc25B and Cdc25C expression levels were significantly greater in cervical cancer patient group than in those of control group. Thus Cdc25 phosphatase might play an important role in carcinogenesis of cervical carcinoma. Further studies based on the correlation between Cdc25 phosphatase and survival rate would be need to support Cdc25 phosphatase as a prognostic factor of cervical carcinoma. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 2156~2165 | - |
dc.relation.isPartOf | Korean Journal of Obstetrics and Gynecology (대한산부인과학회지) | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | 자궁경부암에서 Cdc25A, Cdc25B 및 Cdc25C의 발현 | - |
dc.title.alternative | Expression of Cdc25A, Cdc25B and Cdc25C in cervical carcinoma | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Obstetrics & Gynecology (산부인과학) | - |
dc.contributor.googleauthor | 김혜연 | - |
dc.contributor.googleauthor | 김재욱 | - |
dc.contributor.googleauthor | 김세광 | - |
dc.contributor.googleauthor | 김영태 | - |
dc.contributor.googleauthor | 김재훈 | - |
dc.contributor.googleauthor | 김성훈 | - |
dc.contributor.googleauthor | 김상운 | - |
dc.contributor.googleauthor | 윤보성 | - |
dc.contributor.googleauthor | 남은지 | - |
dc.contributor.googleauthor | 조혜진 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00595 | - |
dc.contributor.localId | A00866 | - |
dc.contributor.localId | A00729 | - |
dc.contributor.localId | A00876 | - |
dc.contributor.localId | A00601 | - |
dc.relation.journalcode | J02076 | - |
dc.subject.keyword | Cervical carcinoma | - |
dc.subject.keyword | Cdc25A | - |
dc.subject.keyword | Cdc25B | - |
dc.subject.keyword | Cdc25C | - |
dc.subject.keyword | RT-PCR | - |
dc.subject.keyword | Western blot analysis | - |
dc.contributor.alternativeName | Kim, Young Tae | - |
dc.contributor.alternativeName | Kim, Jae Wook | - |
dc.contributor.alternativeName | Kim, Jae Hoon | - |
dc.contributor.alternativeName | Kim, Sung Hoon | - |
dc.contributor.alternativeName | Kim, Sei Kwang | - |
dc.contributor.affiliatedAuthor | Kim, Sung Hoon | - |
dc.contributor.affiliatedAuthor | Kim, Jae Wook | - |
dc.contributor.affiliatedAuthor | Kim, Young Tae | - |
dc.contributor.affiliatedAuthor | Kim, Jae Hoon | - |
dc.contributor.affiliatedAuthor | Kim, Sei Kwang | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 49 | - |
dc.citation.number | 10 | - |
dc.citation.startPage | 2156 | - |
dc.citation.endPage | 2165 | - |
dc.identifier.bibliographicCitation | Korean Journal of Obstetrics and Gynecology (대한산부인과학회지), Vol.49(10) : 2156-2165, 2006 | - |
dc.identifier.rimsid | 38076 | - |
dc.type.rims | ART | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.