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Prognostic factors and expression of p53 and mdm-2 in uterine sarcomas

DC Field Value Language
dc.contributor.author김성훈-
dc.contributor.author김영태-
dc.contributor.author김재욱-
dc.contributor.author김재훈-
dc.date.accessioned2015-06-10T12:41:24Z-
dc.date.available2015-06-10T12:41:24Z-
dc.date.issued2006-
dc.identifier.issn0020-7292-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/110269-
dc.description.abstractObjectives: To evaluate the clinicopathologic prognostic factors of uterine sarcoma, and determine whether overexpression of p53 and mdm-2 proteins correlate with overall survival and prognostic factors. Methods: Thirty specimens from 43 patients with uterine sarcoma were available for slide review and evaluated by immunohistochemistry at Yonsei and Ajou University Medical Centers for the expression of p53 and mdm-2. Results: Overall survival was found to correlate to histologic type of uterine sarcoma, surgical stage, tumor grade, and mitotic index. Whereas 63% of the sarcomas expressed p53, with a significant correlation to overall survival, 60% expressed mdm-2, with a significant correlation to the mitotic index but not to overall survival. Conclusion: Histologic type, surgical stage, tumor grade, mitotic index, and p53 expression were prognostic factors of the overall survival of patients with uterine sarcoma.-
dc.description.statementOfResponsibilityopen-
dc.format.extent272~277-
dc.relation.isPartOfINTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHAged, 80 and over-
dc.subject.MESHFemale-
dc.subject.MESHGene Expression/physiology-
dc.subject.MESHHumans-
dc.subject.MESHImmunohistochemistry-
dc.subject.MESHKorea-
dc.subject.MESHMiddle Aged-
dc.subject.MESHNeoplasm Staging/adverse effects*-
dc.subject.MESHPrognosis-
dc.subject.MESHProto-Oncogene Proteins c-mdm2/metabolism*-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHSarcoma/metabolism*-
dc.subject.MESHSarcoma/pathology-
dc.subject.MESHSurvival Analysis-
dc.subject.MESHTumor Suppressor Protein p53/metabolism*-
dc.subject.MESHUp-Regulation/physiology-
dc.subject.MESHUterine Neoplasms/metabolism*-
dc.subject.MESHUterine Neoplasms/pathology-
dc.titlePrognostic factors and expression of p53 and mdm-2 in uterine sarcomas-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Obstetrics & Gynecology (산부인과학)-
dc.contributor.googleauthorS.H. Kim-
dc.contributor.googleauthorJ.W. Kim-
dc.contributor.googleauthorY.T. Kim-
dc.contributor.googleauthorJ.H. Kim-
dc.contributor.googleauthorB.S. Yoon-
dc.contributor.googleauthorH.S. Ryu-
dc.identifier.doi10.1016/j.ijgo.2006.03.031-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00595-
dc.contributor.localIdA00866-
dc.contributor.localIdA00729-
dc.contributor.localIdA00876-
dc.relation.journalcodeJ01117-
dc.identifier.eissn1879-3479-
dc.identifier.pmid16930603-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S0020729206001640-
dc.subject.keywordUterine sarcoma-
dc.subject.keywordClinicopathologic prognostic factors-
dc.subject.keywordp53 protein-
dc.subject.keywordmdm-2 protein-
dc.contributor.alternativeNameKim, Sung Hoon-
dc.contributor.alternativeNameKim, Young Tae-
dc.contributor.alternativeNameKim, Jae Wook-
dc.contributor.alternativeNameKim, Jae Hoon-
dc.contributor.affiliatedAuthorKim, Sung Hoon-
dc.contributor.affiliatedAuthorKim, Jae Wook-
dc.contributor.affiliatedAuthorKim, Young Tae-
dc.contributor.affiliatedAuthorKim, Jae Hoon-
dc.rights.accessRightsnot free-
dc.citation.volume95-
dc.citation.number3-
dc.citation.startPage272-
dc.citation.endPage277-
dc.identifier.bibliographicCitationINTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS, Vol.95(3) : 272-277, 2006-
dc.identifier.rimsid38074-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Obstetrics and Gynecology (산부인과학교실) > 1. Journal Papers
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