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Transcriptional regulation of artemin is related to neurite outgrowth and actin polymerization in mature DRG neurons

DC Field Value Language
dc.contributor.author홍용우-
dc.date.accessioned2015-06-10T12:41:18Z-
dc.date.available2015-06-10T12:41:18Z-
dc.date.issued2006-
dc.identifier.issn0304-3940-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/110266-
dc.description.abstractArtemin is a member of the glial cell line-derived neurotrophic factor (GDNF) family of ligands that helps to ensure the survival of sensory neurons. We used an in vitro isolated dorsal root ganglia model to study the effects of artemin on the adult rat neuronal system and investigate differentially regulated genes. We found that 285 genes were differentially transcribed by artemin after 3 h of treatment, including genes related to cell adhesion and actin polymerization. A series of genes involved in the regulation of actin dynamics, including coronin, Myr 5, Wiskott–Aldrich syndrome protein interacting protein, cofilin, drebrin and dynamin were down-regulated by artemin, suggesting that it plays a previously undefined role in the regulation of actin polymerization and synaptic vesicle movement. Artemin also down-regulated the expression of genes related to cell adhesion and matrix assembly, including biglycan, plectin, nestin, neuronatin and the neuron-glia-CAM-related cell adhesion molecule, which is functionally relevant to neurite elongation in DRG neurons. Artemin resulted in increases in total neurite length and branching of the DRG neurons. Also artemin caused an increase of synaptic vesicle clustering. Our results showed that the inhibition of DNA methylation suppressed the artemin-dependent neurite growth, suggesting that the genetic regulation could be relevant to neurite elongation in mature DRG.-
dc.description.statementOfResponsibilityopen-
dc.format.extent61~66-
dc.relation.isPartOfNEUROSCIENCE LETTERS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHActins/metabolism*-
dc.subject.MESHAnimals-
dc.subject.MESHCell Adhesion/genetics-
dc.subject.MESHExtracellular Matrix/genetics-
dc.subject.MESHGanglia, Spinal/physiology*-
dc.subject.MESHGene Expression Regulation-
dc.subject.MESHNerve Tissue Proteins/genetics*-
dc.subject.MESHNeurites/physiology*-
dc.subject.MESHNeurons/physiology*-
dc.subject.MESHRats-
dc.subject.MESHRats, Sprague-Dawley-
dc.subject.MESHTranscription, Genetic*-
dc.titleTranscriptional regulation of artemin is related to neurite outgrowth and actin polymerization in mature DRG neurons-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Anesthesiology (마취통증의학)-
dc.contributor.googleauthorSeyeon Park-
dc.contributor.googleauthorYong-Woo Hong-
dc.identifier.doi10.1016/j.neulet.2006.05.041-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA04420-
dc.relation.journalcodeJ02364-
dc.identifier.eissn1872-7972-
dc.identifier.pmid16781061-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S0304394006005283-
dc.subject.keywordArtemin-
dc.subject.keywordNeurite growth-
dc.subject.keywordActin polymerization-
dc.subject.keywordMicroarray-
dc.contributor.alternativeNameHong, Yong Woo-
dc.contributor.affiliatedAuthorHong, Yong Woo-
dc.rights.accessRightsnot free-
dc.citation.volume404-
dc.citation.number1-2-
dc.citation.startPage61-
dc.citation.endPage66-
dc.identifier.bibliographicCitationNEUROSCIENCE LETTERS, Vol.404(1-2) : 61-66, 2006-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 1. Journal Papers

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