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한국인에서의 편두통과 도파민 D4수용체 유전자 다형태의 연관성
DC Field | Value | Language |
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dc.contributor.author | 김원주 | - |
dc.contributor.author | 이경열 | - |
dc.contributor.author | 최영철 | - |
dc.date.accessioned | 2015-06-10T12:39:30Z | - |
dc.date.available | 2015-06-10T12:39:30Z | - |
dc.date.issued | 2006 | - |
dc.identifier.issn | 1598-009X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/110211 | - |
dc.description.abstract | Background: The dopam ine m etabolism is believed to play an important part in the pathophysiology of migraines. It was reported that the distribution of alleles for the dopamine D4 receptor gene (DRD4) in migraine w ithout aura patients is significantly different from those in control group. A polymorphism of the D RD4 m ight be related to genetic susceptibility of m igraine. The aim of this study w as to investigate the association of DRD4 exon III polymorphism between patient group w ith m igraine and control group. Methods: This study compared 150 patients with m igraine (38 m ales, 112 females and m ean age 42.4±10.23) 100 healthy control subjects (25 males, 75 females and mean age 42.6±10.35) in order to determine the association between a polymorphism of the DRD4 exon III and m igraine. Using PCR techniques, the DRD4 polymorphism was denoted by 48-base-pair tandem repeat in exon III of the gene. Results: There w as no significant difference between the healthy controls, m igraine without aura patients and m igraine with aura patients in age and sex distribution. Significant differences w ere noted in the genotype betw een m igraine without aura group and m igraine w ith aura group. Also significant differences w ere observed in allele frequencies compared m igraine w ithout patients w ith control group and m igraine w ith aura patients. Conclusions: The DRD4 polymorphism appears to be involved in the genetic predisposition to m igraine w ithout aura. Migraine w ithout aura m ay have different pathophysiology from m igraine w ith aura in genetic field. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 41~45 | - |
dc.relation.isPartOf | Korean Journal of Headache (두통) | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | 한국인에서의 편두통과 도파민 D4수용체 유전자 다형태의 연관성 | - |
dc.title.alternative | Dopamine D4 Receptor Gene Polymorphism in Korean Patients with Migraine | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Neurology (신경과학) | - |
dc.contributor.googleauthor | 송태진 | - |
dc.contributor.googleauthor | 홍지만 | - |
dc.contributor.googleauthor | 김현숙 | - |
dc.contributor.googleauthor | 이경열 | - |
dc.contributor.googleauthor | 김원주 | - |
dc.contributor.googleauthor | 최영철 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00771 | - |
dc.contributor.localId | A02648 | - |
dc.contributor.localId | A04116 | - |
dc.relation.journalcode | J02023 | - |
dc.subject.keyword | Migraine | - |
dc.subject.keyword | Dopamine D4 Receptor Gene Polym orphism | - |
dc.subject.keyword | Allele | - |
dc.contributor.alternativeName | Kim, Won Joo | - |
dc.contributor.alternativeName | Lee, Kyung Yul | - |
dc.contributor.alternativeName | Choi, Young Chul | - |
dc.contributor.affiliatedAuthor | Kim, Won Joo | - |
dc.contributor.affiliatedAuthor | Lee, Kyung Yul | - |
dc.contributor.affiliatedAuthor | Choi, Young Chul | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 7 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 41 | - |
dc.citation.endPage | 45 | - |
dc.identifier.bibliographicCitation | Korean Journal of Headache (두통), Vol.7(1) : 41-45, 2006 | - |
dc.identifier.rimsid | 53005 | - |
dc.type.rims | ART | - |
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