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한국인에서의 편두통과 도파민 D4수용체 유전자 다형태의 연관성

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dc.contributor.author김원주-
dc.contributor.author이경열-
dc.contributor.author최영철-
dc.date.accessioned2015-06-10T12:39:30Z-
dc.date.available2015-06-10T12:39:30Z-
dc.date.issued2006-
dc.identifier.issn1598-009X-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/110211-
dc.description.abstractBackground: The dopam ine m etabolism is believed to play an important part in the pathophysiology of migraines. It was reported that the distribution of alleles for the dopamine D4 receptor gene (DRD4) in migraine w ithout aura patients is significantly different from those in control group. A polymorphism of the D RD4 m ight be related to genetic susceptibility of m igraine. The aim of this study w as to investigate the association of DRD4 exon III polymorphism between patient group w ith m igraine and control group. Methods: This study compared 150 patients with m igraine (38 m ales, 112 females and m ean age 42.4±10.23) 100 healthy control subjects (25 males, 75 females and mean age 42.6±10.35) in order to determine the association between a polymorphism of the DRD4 exon III and m igraine. Using PCR techniques, the DRD4 polymorphism was denoted by 48-base-pair tandem repeat in exon III of the gene. Results: There w as no significant difference between the healthy controls, m igraine without aura patients and m igraine with aura patients in age and sex distribution. Significant differences w ere noted in the genotype betw een m igraine without aura group and m igraine w ith aura group. Also significant differences w ere observed in allele frequencies compared m igraine w ithout patients w ith control group and m igraine w ith aura patients. Conclusions: The DRD4 polymorphism appears to be involved in the genetic predisposition to m igraine w ithout aura. Migraine w ithout aura m ay have different pathophysiology from m igraine w ith aura in genetic field.-
dc.description.statementOfResponsibilityopen-
dc.format.extent41~45-
dc.relation.isPartOfKorean Journal of Headache (두통)-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.title한국인에서의 편두통과 도파민 D4수용체 유전자 다형태의 연관성-
dc.title.alternativeDopamine D4 Receptor Gene Polymorphism in Korean Patients with Migraine-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Neurology (신경과학)-
dc.contributor.googleauthor송태진-
dc.contributor.googleauthor홍지만-
dc.contributor.googleauthor김현숙-
dc.contributor.googleauthor이경열-
dc.contributor.googleauthor김원주-
dc.contributor.googleauthor최영철-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00771-
dc.contributor.localIdA02648-
dc.contributor.localIdA04116-
dc.relation.journalcodeJ02023-
dc.subject.keywordMigraine-
dc.subject.keywordDopamine D4 Receptor Gene Polym orphism-
dc.subject.keywordAllele-
dc.contributor.alternativeNameKim, Won Joo-
dc.contributor.alternativeNameLee, Kyung Yul-
dc.contributor.alternativeNameChoi, Young Chul-
dc.contributor.affiliatedAuthorKim, Won Joo-
dc.contributor.affiliatedAuthorLee, Kyung Yul-
dc.contributor.affiliatedAuthorChoi, Young Chul-
dc.rights.accessRightsfree-
dc.citation.volume7-
dc.citation.number1-
dc.citation.startPage41-
dc.citation.endPage45-
dc.identifier.bibliographicCitationKorean Journal of Headache (두통), Vol.7(1) : 41-45, 2006-
dc.identifier.rimsid53005-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers

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