Cited 12 times in
Relationship between neurokinin 2 receptor gene polymorphisms and serum vascular endothelial growth factor levels in patients with toluene diisocyanate-induced asthma
DC Field | Value | Language |
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dc.contributor.author | 홍천수 | - |
dc.date.accessioned | 2015-06-10T12:38:24Z | - |
dc.date.available | 2015-06-10T12:38:24Z | - |
dc.date.issued | 2006 | - |
dc.identifier.issn | 0954-7894 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/110176 | - |
dc.description.abstract | BACKGROUND: Among the various pathogenic mechanisms of toluene diisocyanate (TDI)-induced asthma, a contribution from neurogenic inflammation has been suggested. OBJECTIVE: To evaluate neurokinin 2 receptor (NK2R) gene polymorphisms in association with the clinical phenotype of TDI-induced asthma, 70 TDI-induced occupational asthma (TDI-OA)patients, 59 asymptomatic exposed controls (AEC), and 93 unexposed healthy controls (NC) were enrolled in the study. METHODS: Two single-nucleotide polymorphisms (SNPs) of NK2R, 7853G>A (Gly231Glu) and 11 424G>A (Arg375His), were genotyped using a single base extension method. The levels of PC20 methacholine, specific IgE and IgG to TDI-human serum albumin conjugate, and serum vascular endothelial growth factor (VEGF), matrix metalloproteinase-9, and TGF-beta1 were compared according to the NK2R genotypes of the subjects with TDI-OA and AEC. RESULTS: No significant differences in allele, genotype, or haplotype frequencies of these two SNPs were noted among the three groups (P>0.05, respectively). Moreover, subjects with the NK2R 7853GG genotype had higher serum VEGF levels than those with GA or AA among the TDI-exposed workers (P=0.040). CONCLUSION: The NK2R 7853GG genotype may contribute to increased serum VEGF levels, which result in airway inflammation after TDI exposure. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 1153~1160 | - |
dc.relation.isPartOf | CLINICAL AND EXPERIMENTAL ALLERGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Asthma/blood | - |
dc.subject.MESH | Asthma/chemically induced | - |
dc.subject.MESH | Asthma/genetics* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Forced Expiratory Volume | - |
dc.subject.MESH | Gene Frequency/genetics | - |
dc.subject.MESH | Genetic Predisposition to Disease/genetics | - |
dc.subject.MESH | Genotype | - |
dc.subject.MESH | Haplotypes/genetics | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Immunoglobulin E/blood | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Occupational Diseases/blood | - |
dc.subject.MESH | Occupational Diseases/chemically induced | - |
dc.subject.MESH | Occupational Diseases/genetics* | - |
dc.subject.MESH | Polymorphism, Single Nucleotide/genetics* | - |
dc.subject.MESH | Receptors, Neurokinin-2/genetics* | - |
dc.subject.MESH | Toluene 2,4-Diisocyanate/toxicity* | - |
dc.subject.MESH | Vascular Endothelial Growth Factor A/blood* | - |
dc.title | Relationship between neurokinin 2 receptor gene polymorphisms and serum vascular endothelial growth factor levels in patients with toluene diisocyanate-induced asthma | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Y.-M. Ye | - |
dc.contributor.googleauthor | Y.-M. Kang | - |
dc.contributor.googleauthor | S.-H. Kim | - |
dc.contributor.googleauthor | C.-W. Kim | - |
dc.contributor.googleauthor | H.-R. Kim | - |
dc.contributor.googleauthor | C.-S. Hong | - |
dc.contributor.googleauthor | C.-S. Park | - |
dc.contributor.googleauthor | H.-M. Kim | - |
dc.contributor.googleauthor | D.-H. Nahm | - |
dc.contributor.googleauthor | H.-S. Park | - |
dc.identifier.doi | 10.1111/j.1365-2222.2006.02547.x | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A04448-1 | - |
dc.relation.journalcode | J00548 | - |
dc.identifier.eissn | 1365-2222 | - |
dc.identifier.pmid | 16961715 | - |
dc.identifier.url | http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2222.2006.02547.x/abstract | - |
dc.subject.keyword | asthma | - |
dc.subject.keyword | genetic susceptibility | - |
dc.subject.keyword | isocyanate | - |
dc.subject.keyword | neurokinin 2 receptor | - |
dc.contributor.alternativeName | Hong, Chein Soo | - |
dc.contributor.affiliatedAuthor | Hong, Chein Soo | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 36 | - |
dc.citation.number | 9 | - |
dc.citation.startPage | 1153 | - |
dc.citation.endPage | 1160 | - |
dc.identifier.bibliographicCitation | CLINICAL AND EXPERIMENTAL ALLERGY, Vol.36(9) : 1153-1160, 2006 | - |
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