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Relationship between neurokinin 2 receptor gene polymorphisms and serum vascular endothelial growth factor levels in patients with toluene diisocyanate-induced asthma

Authors
 Y.-M. Ye  ;  Y.-M. Kang  ;  S.-H. Kim  ;  C.-W. Kim  ;  H.-R. Kim  ;  C.-S. Hong  ;  C.-S. Park  ;  H.-M. Kim  ;  D.-H. Nahm  ;  H.-S. Park 
Citation
 CLINICAL AND EXPERIMENTAL ALLERGY, Vol.36(9) : 1153-1160, 2006 
Journal Title
 CLINICAL AND EXPERIMENTAL ALLERGY 
ISSN
 0954-7894 
Issue Date
2006
MeSH
Adult ; Asthma/blood ; Asthma/chemically induced ; Asthma/genetics* ; Female ; Forced Expiratory Volume ; Gene Frequency/genetics ; Genetic Predisposition to Disease/genetics ; Genotype ; Haplotypes/genetics ; Humans ; Immunoglobulin E/blood ; Male ; Middle Aged ; Occupational Diseases/blood ; Occupational Diseases/chemically induced ; Occupational Diseases/genetics* ; Polymorphism, Single Nucleotide/genetics* ; Receptors, Neurokinin-2/genetics* ; Toluene 2,4-Diisocyanate/toxicity* ; Vascular Endothelial Growth Factor A/blood*
Keywords
asthma ; genetic susceptibility ; isocyanate ; neurokinin 2 receptor
Abstract
BACKGROUND: Among the various pathogenic mechanisms of toluene diisocyanate (TDI)-induced asthma, a contribution from neurogenic inflammation has been suggested. OBJECTIVE: To evaluate neurokinin 2 receptor (NK2R) gene polymorphisms in association with the clinical phenotype of TDI-induced asthma, 70 TDI-induced occupational asthma (TDI-OA)patients, 59 asymptomatic exposed controls (AEC), and 93 unexposed healthy controls (NC) were enrolled in the study. METHODS: Two single-nucleotide polymorphisms (SNPs) of NK2R, 7853G>A (Gly231Glu) and 11 424G>A (Arg375His), were genotyped using a single base extension method. The levels of PC20 methacholine, specific IgE and IgG to TDI-human serum albumin conjugate, and serum vascular endothelial growth factor (VEGF), matrix metalloproteinase-9, and TGF-beta1 were compared according to the NK2R genotypes of the subjects with TDI-OA and AEC. RESULTS: No significant differences in allele, genotype, or haplotype frequencies of these two SNPs were noted among the three groups (P>0.05, respectively). Moreover, subjects with the NK2R 7853GG genotype had higher serum VEGF levels than those with GA or AA among the TDI-exposed workers (P=0.040). CONCLUSION: The NK2R 7853GG genotype may contribute to increased serum VEGF levels, which result in airway inflammation after TDI exposure.
Full Text
http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2222.2006.02547.x/abstract
DOI
10.1111/j.1365-2222.2006.02547.x
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Hong, Chein Soo(홍천수)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/110176
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