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An update of the defensive barrier function of skin

Authors
 Seung Hun Lee  ;  Se Kyoo Jeong  ;  Sung Ku Ahn 
Citation
 YONSEI MEDICAL JOURNAL, Vol.47(3) : 293-306, 2006 
Journal Title
YONSEI MEDICAL JOURNAL
ISSN
 0513-5796 
Issue Date
2006
MeSH
Animals ; Humans ; Permeability ; Skin/metabolism* ; Skin Diseases/metabolism* ; Skin Diseases/physiopathology ; Skin Physiological Phenomena*
Keywords
Epidermal calcium gradient ; epidermal permeability barrier ; keratinocyte differentiation ; lamellar body ; nuclear hormone receptors ; protease-activated receptor-2 ; skin pH
Abstract
Skin, as the outermost organ in the human body, continuously confronts the external environment and serves as a primary defense system. The protective functions of skin include UV-protection, anti-oxidant and antimicrobial functions. In addition to these protections, skin also acts as a sensory organ and the primary regulator of body temperature. Within these important functions, the epidermal permeability barrier, which controls the transcutaneous movement of water and other electrolytes, is probably the most important. This permeability barrier resides in the stratum corneum, a resilient layer composed of corneocytes and stratum corneum intercellular lipids. Since the first realization of the structural and biochemical diversities involved in the stratum corneum, a tremendous amount of work has been performed to elucidate its roles and functions in the skin, and in humans in general. The perturbation of the epidermal permeability barrier, previously speculated to be just a symptom involved in skin diseases, is currently considered to be a primary pathophysiologic factor for many skin diseases. In addition, much of the evidence provides support for the idea that various protective functions in the skin are closely related or even co-regulated. In this review, the recent achievements of skin researchers focusing on the functions of the epidermal permeability barrier and their importance in skin disease, such as atopic dermatitis and psoriasis, are introduced.
Files in This Item:
T200601112.pdf Download
DOI
10.3349/ymj.2006.47.3.293
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Dermatology (피부과학교실) > 1. Journal Papers
Yonsei Authors
Lee, Seung Hun(이승헌)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/110076
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