Cited 3 times in
전립선비대증 환자에서α-차단제 및 Finasteride 병용치료에 따른 PSA의 변화 양상: 3년간 추적관찰 결과
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 정병하 | - |
dc.date.accessioned | 2015-06-10T12:33:17Z | - |
dc.date.available | 2015-06-10T12:33:17Z | - |
dc.date.issued | 2006 | - |
dc.identifier.issn | 0494-4747 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/110017 | - |
dc.description.abstract | Purpose: Some recent studies have demonstrated that finasteride, a well-known 5α-reductase inhibitor, can decrease prostate specific antigen (PSA) by approximately 50% during the first 1 year of treatment. We investigated how long-term treatment with finasteride and α-blockers impacts on the serum PSA level of men whose final diagnosis was benign prostatic hyperplasia (BPH). Materials and Methods: In a retrospective trial, we evaluated a total of 293 men with lower urinary tract symptoms (LUTS) that were suggestive of BPH. These men were divided into two treatment groups: group A was treated with α-blockers and group C was treated with a combination of finasteride and α-blocker. Comparisons of the two groups were performed by using independent t-tests. The changes in the PSA concentrations from baseline to the time of the final measurements were determined by repeated measures of ANOVA. Results: There was no significant difference in the baseline PSA between the two groups. A statistically significant reduction in the PSA levels was observed at 2 years in C group (p<0.05), whereas any significant increase were not observed in group A (p>0.05). In group A, the repeatedly measured PSA levels were 2.67, 2.40, 2.41 and 2.42, respectively. In C group, these were 3.22, 2.09, 1.81 and 1.71 respectively. Conclusions: Our data showed that there was no clinically significant effect of long term treatment with α-blocker on the PSA levels. However, finasteride had significant effect on the serum PSA level during first two years of treatment. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 372~376 | - |
dc.relation.isPartOf | KOREAN JOURNAL OF UROLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | 전립선비대증 환자에서α-차단제 및 Finasteride 병용치료에 따른 PSA의 변화 양상: 3년간 추적관찰 결과 | - |
dc.title.alternative | The Changing Pattern of Serum Prostate Specific Antigen in Patients with Benign Prostatic Hyperplasia after Combined Treatment with Finasteride and α-blockers: the 3 Year Follow-up Data | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Urology (비뇨기과학) | - |
dc.contributor.googleauthor | 소병현 | - |
dc.contributor.googleauthor | 이재석 | - |
dc.contributor.googleauthor | 정병하 | - |
dc.identifier.doi | 10.4111/kju.2006.47.4.372 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A03607 | - |
dc.relation.journalcode | J02135 | - |
dc.subject.keyword | Prostatic hyperplasia | - |
dc.subject.keyword | Adrenergic antagonist | - |
dc.subject.keyword | Reductase | - |
dc.subject.keyword | Prostate specific antigen | - |
dc.contributor.alternativeName | Chung, Byung Ha | - |
dc.contributor.affiliatedAuthor | Chung, Byung Ha | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 47 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 372 | - |
dc.citation.endPage | 376 | - |
dc.identifier.bibliographicCitation | KOREAN JOURNAL OF UROLOGY, Vol.47(4) : 372-376, 2006 | - |
dc.identifier.rimsid | 56025 | - |
dc.type.rims | ART | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.