Cited 77 times in
Dissemination of 16S rRNA methylase-mediated highly amikacin-resistant isolates of Klebsiella pneumoniae and Acinetobacter baumannii in Korea
DC Field | Value | Language |
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dc.contributor.author | 용동은 | - |
dc.contributor.author | 이경원 | - |
dc.date.accessioned | 2015-06-10T12:30:57Z | - |
dc.date.available | 2015-06-10T12:30:57Z | - |
dc.date.issued | 2006 | - |
dc.identifier.issn | 0732-8893 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/109944 | - |
dc.description.abstract | Novel 16S rRNA methylase-mediated high-level resistance to amikacin and arbekacin has been reported recently in clinical isolates of Gram-negative bacilli only from several countries. We tested amikacin- or arbekacin-nonsusceptible Gram-negative bacilli isolated in 2003 and 2005 at a tertiary-care hospital in Korea by polymerase chain reaction to detect 16S rRNA methylase genes. armA alleles were detected in 14 isolates of Klebsiella pneumoniae, 10 other species of Enterobacteriaceae, and 16 Acinetobacter baumannii, whereas the rmtB allele was detected in 1 K. pneumoniae isolate. The resistance 1st detected in 2003 persisted in 2005. 16S rRNA methylase-producing isolates were highly resistant to arbekacin and amikacin, and were mostly coresistant to levofloxacin. Most K. pneumoniae isolates also produced extended-spectrum β-lactamases and plasmid-mediated AmpC β-lactamases, and most A. baumannii isolates were nonsusceptible to carbapenems. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 305~312 | - |
dc.relation.isPartOf | DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Acinetobacter baumannii/drug effects | - |
dc.subject.MESH | Acinetobacter baumannii/enzymology | - |
dc.subject.MESH | Acinetobacter baumannii/isolation & purification* | - |
dc.subject.MESH | Amikacin/pharmacology | - |
dc.subject.MESH | Aminoglycosides/pharmacology* | - |
dc.subject.MESH | Conjugation, Genetic | - |
dc.subject.MESH | Drug Resistance, Bacterial/physiology | - |
dc.subject.MESH | Electrophoresis, Gel, Pulsed-Field | - |
dc.subject.MESH | Klebsiella pneumoniae/drug effects | - |
dc.subject.MESH | Klebsiella pneumoniae/enzymology | - |
dc.subject.MESH | Klebsiella pneumoniae/isolation & purification* | - |
dc.subject.MESH | Korea/epidemiology | - |
dc.subject.MESH | Methyltransferases/metabolism* | - |
dc.subject.MESH | Microbial Sensitivity Tests | - |
dc.subject.MESH | RNA, Ribosomal, 16S/metabolism | - |
dc.title | Dissemination of 16S rRNA methylase-mediated highly amikacin-resistant isolates of Klebsiella pneumoniae and Acinetobacter baumannii in Korea | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Laboratory Medicine (진단검사의학) | - |
dc.contributor.googleauthor | Hyukmin Lee | - |
dc.contributor.googleauthor | Dongeun Yong | - |
dc.contributor.googleauthor | Jong Hwa Yum | - |
dc.contributor.googleauthor | Kyoung Ho Roh | - |
dc.contributor.googleauthor | Kyungwon Lee | - |
dc.contributor.googleauthor | Kunikazu Yamane | - |
dc.contributor.googleauthor | Yoshichika Arakawa | - |
dc.contributor.googleauthor | Yunsop Chong | - |
dc.identifier.doi | 10.1016/j.diagmicrobio.2006.05.002 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02423 | - |
dc.contributor.localId | A02649 | - |
dc.relation.journalcode | J00731 | - |
dc.identifier.eissn | 1879-0070 | - |
dc.identifier.pmid | 16822637 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0732889306001957 | - |
dc.subject.keyword | 16S rRNA methylase | - |
dc.subject.keyword | armA | - |
dc.subject.keyword | rmtB | - |
dc.subject.keyword | High-level aminoglycoside resistance | - |
dc.contributor.alternativeName | Yong, Dong Eun | - |
dc.contributor.alternativeName | Lee, Kyung Won | - |
dc.contributor.affiliatedAuthor | Yong, Dong Eun | - |
dc.contributor.affiliatedAuthor | Lee, Kyung Won | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 56 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 305 | - |
dc.citation.endPage | 312 | - |
dc.identifier.bibliographicCitation | DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE, Vol.56(3) : 305-312, 2006 | - |
dc.identifier.rimsid | 55036 | - |
dc.type.rims | ART | - |
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