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근치적 신절제술 시 관찰된 동측 신의 다발성 신세포암의 빈도 및 병리조직학적 예측인자

Other Titles
 The Incidence and Clinicopathologic Predictable Factors for Multifocality in the Patients Who had Radical Nephrectomy Performed for Renal Cell Carcinoma 
Authors
 소병현  ;  한웅규  ;  양승철 
Citation
 KOREAN JOURNAL OF UROLOGY, Vol.47(5) : 462-466, 2006 
Journal Title
KOREAN JOURNAL OF UROLOGY(대한비뇨기과학회지)
ISSN
 0494-4747 
Issue Date
2006
Keywords
Multifocality ; Renal cell carcinoma ; Nephrectomy
Abstract
Purpose: We aimed to assess the influence of the clinical and pathological factors on the multifocality of renal cell carcinoma.

Materials and Methods: We retrospectively reviewed the records of 467 patients (mean age: 54.6 years) who underwent operation for renal cell carcinoma at this hospital between June 1995 and April 2004. We evaluated the pathologic stage, grade, cell type, the histological pattern, tumor necrosis, the tumor size and the features of multifocality. To determine the clinical significant factors related with multifocality in renal cell carcinoma, we used the chi square test and multiple logistic regression analysis.

Results: Of the 467 renal cell carcinomas, 27 cases (5.8%) had multifocal malignant nodules. The average size of the multifocal renal lesions was 17×12×9 mm. The incidence of multifocality was statistically higher in the patients with stage pT3 disease than in those patients with stage pT1 or pT2 disease (p<0.001), and it was also higher for those patients with nuclear grade 3 or 4 than for those patients with nuclear grade 1 and 2 (p=0.005). Only the stage had significant correlation with multifocal disease when performing multiple logistic regression analysis.

Conclusions: Our results suggest that the primary tumor stage is a risk factor for multifocality in the patients with renal cell carcinoma. Therefore, more precise preoperative staging of the primary tumor is required in case of performing nephron sparing surgery.
Files in This Item:
T200600976.pdf Download
DOI
10.4111/kju.2006.47.5.462
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Urology (비뇨의학교실) > 1. Journal Papers
Yonsei Authors
Soh, Byung Hyun(소병현)
Yang, Seung Choul(양승철)
Han, Woong Kyu(한웅규) ORCID logo https://orcid.org/0000-0002-2527-4046
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/109936
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