Increasing Prevalence and Diversity of Metallo-β-Lactamases in Pseudomonas spp., Acinetobacter spp., and Enterobacteriaceae from Korea

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Authors: Dongeun Yong ; Yeoung Seon Choi ; Kyoung Ho Roh ; Chang Ki Kim ; Youn Hee Park ; Jong Hwa Yum ; Kyungwon Lee ; Yunsop Chong

Citation: ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, Vol.50(5) : 1884-1886, 2006

MeSH: Acinetobacter/classification ; Acinetobacter/enzymology* ; Acinetobacter/genetics ; Acinetobacter/growth & development ; Acinetobacter/isolation & purification ; Enterobacteriaceae/enzymology* ; Enterobacteriaceae/genetics ; Enterobacteriaceae/growth & development ; Enterobacteriaceae/isolation & purification ; Genes, Bacterial ; Genetic Variation* ; Humans ; Korea/epidemiology ; Prevalence* ; Pseudomonas/classification ; Pseudomonas/enzymology* ; Pseudomonas/genetics ; Pseudomonas/growth & development ; Pseudomonas/isolation & purification ; Sputum/microbiology ; Urine/microbiology ; beta-Lactamases/genetics*

Abstract: Among imipenem-nonsusceptible isolates, acquired metallo-beta-lactamase genes were detected in 36 of 581 (6.2%) Pseudomonas aeruginosa isolates, 42 of 44 (95.4%) other Pseudomonas species, and 136 of 513 (26.5%) Acinetobacter species from 2003 to 2004 at a Korean hospital. Overall, bla(VIM-2)-like genes were the most prevalent and were also detected in Enterobacteriaceae, including Klebsiella pneumoniae.