Cited 55 times in
Prevalence of plasmid-mediated AmpC β-lactamases in Escherichia coli and Klebsiella pneumoniae in Korea
DC Field | Value | Language |
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dc.contributor.author | 용동은 | - |
dc.contributor.author | 이경원 | - |
dc.date.accessioned | 2015-06-10T12:29:43Z | - |
dc.date.available | 2015-06-10T12:29:43Z | - |
dc.date.issued | 2006 | - |
dc.identifier.issn | 1076-6294 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/109906 | - |
dc.description.abstract | Cefoxitin-resistant Escherichia coli and Klebsiella pneumoniae are relatively prevalent in Korea, suggesting dissemination of plasmid-mediated AmpC β-lactamases. In this study, 238 isolates of cefoxitin-resistant E. coli and K. pneumoniae (not including subspecies ozaenae and rhinoscleromatis) were collected in 2003 from 16 Korean hospitals. The prevalence of plasmid-mediated AmpC β-lactamases was determined by PCR. The AmpC gene alleles detected in E. coli and K. pneumoniae were bla DHA-1, 10 (8.6%) and 93 (76.2%); bla CMY-1-like, 14 (12.1%) and 2 (1.6%); and bla CMY-2-like, 38 (32.7%) and 1 (0.8%) isolates, respectively. The genes identified were bla DHA-1, bla CMY10-like, and bla CMY-2-like, and a new variant, bla CMY-18. Plasmidmediated AmpC gene allele-positive isolates were present both in large city and in small province hospitals, as well as in isolates from outpatients. The proportions of plasmid-mediated AmpC gene-positive isolates were similar in both expanded spectrum β-lactamase (ESBL)-producing and -nonproducing isolates. In conclusion, DHA-1, CMY-2-like, and CMY-10-like plasmid-mediated AmpC β-lactamase-producing K. pneumoniae and E. coli isolates are widely disseminated in both large city and small province hospitals. Absence of bla CMY-1 and detection of a novel variant of bla CMY-2, bla CMY-18, indicate continued evolution of the prototype genes. Similar proportions of plasmid-mediated AmpC gene-positive isolates in both ESBL-producing and -nonproducing isolates suggest unhindered future spread of these resistances. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 44~49 | - |
dc.relation.isPartOf | MICROBIAL DRUG RESISTANCE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Bacterial Proteins/genetics* | - |
dc.subject.MESH | Escherichia coli/enzymology* | - |
dc.subject.MESH | Klebsiella pneumoniae/enzymology* | - |
dc.subject.MESH | Klebsiella pneumoniae/genetics | - |
dc.subject.MESH | Korea | - |
dc.subject.MESH | Plasmids* | - |
dc.subject.MESH | beta-Lactamases/genetics* | - |
dc.title | Prevalence of plasmid-mediated AmpC β-lactamases in Escherichia coli and Klebsiella pneumoniae in Korea | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Laboratory Medicine (진단검사의학) | - |
dc.contributor.googleauthor | Kyungwon Lee | - |
dc.contributor.googleauthor | Miae Lee | - |
dc.contributor.googleauthor | Jong Hee Shin | - |
dc.contributor.googleauthor | Myung Hee Lee | - |
dc.contributor.googleauthor | Sung Ha Kang | - |
dc.contributor.googleauthor | Ae Ja Park | - |
dc.contributor.googleauthor | Dongeun Yong | - |
dc.contributor.googleauthor | Yunsop Chong | - |
dc.identifier.doi | 10.1089/mdr.2006.12.44 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02423 | - |
dc.contributor.localId | A02649 | - |
dc.relation.journalcode | J02229 | - |
dc.identifier.eissn | 1931-8448 | - |
dc.identifier.pmid | 16584308 | - |
dc.identifier.url | http://online.liebertpub.com/doi/abs/10.1089/mdr.2006.12.44 | - |
dc.contributor.alternativeName | Yong, Dong Eun | - |
dc.contributor.alternativeName | Lee, Kyung Won | - |
dc.contributor.affiliatedAuthor | Yong, Dong Eun | - |
dc.contributor.affiliatedAuthor | Lee, Kyung Won | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 12 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 44 | - |
dc.citation.endPage | 49 | - |
dc.identifier.bibliographicCitation | MICROBIAL DRUG RESISTANCE, Vol.12(1) : 44-49, 2006 | - |
dc.identifier.rimsid | 55006 | - |
dc.type.rims | ART | - |
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