Cited 10 times in
Plasma level of IL-6 and its relationship to procoagulant and fibrinolytic markers in acute ischemic stroke
DC Field | Value | Language |
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dc.contributor.author | 송경순 | - |
dc.contributor.author | 송재우 | - |
dc.contributor.author | 최종락 | - |
dc.date.accessioned | 2015-06-10T12:29:20Z | - |
dc.date.available | 2015-06-10T12:29:20Z | - |
dc.date.issued | 2006 | - |
dc.identifier.issn | 0513-5796 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/109894 | - |
dc.description.abstract | Procoagulant or impaired fibrinolytic states as well as inflammatory reactions mediated by cytokines are likely involved in the pathogenesis of acute ischemic stroke. We examined the potential relationship between interleukin 6 (IL-6) and hemostatic markers. The procoagulant and fibrinolytic states were assessed in 46 patients with acute stroke by measuring plasma levels of plasminogen activator inhibitor-1 (PAI-1), thrombin-antithrombin complex (TAT), and plasminogen-antiplasmin complex (PAP). Circulating IL-6 levels were measured using ELISA (Quantikine, R&D systems, MN, USA). Circulating IL-6 (mean, 26.5 pg/mL) and PAI-1 (mean, 19.9 ng/mL) levels were higher in patients with acute stroke than in healthy subjects (mean, 3.0 pg/mL, 10.4 ng/mL, respectively). TAT levels were statistically different according to the etiologic subtypes of stroke (atherogenic, 2.5 ng/mL; lacunar 3.2 ng/mL; cardiogenic 9.9 ng/mL, p = 0.021). Neither procoagulant levels nor fibrinolytic markers significantly correlated with circulating IL-6 levels. Our findings suggest that elevated proinflammatory cytokines during the initial hours of ischemic stroke may be an independent pathogenic factor or a consequence of the thrombotic event with no relationship to the procoagulant or fibrinolytic states. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 201~206 | - |
dc.relation.isPartOf | YONSEI MEDICAL JOURNAL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Acute Disease | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Antithrombins/chemistry | - |
dc.subject.MESH | Blood Coagulation Factors/metabolism | - |
dc.subject.MESH | Coagulants/metabolism* | - |
dc.subject.MESH | Cytokines/metabolism | - |
dc.subject.MESH | Enzyme-Linked Immunosorbent Assay | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Fibrinolysis* | - |
dc.subject.MESH | Hemostasis | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Interleukin-6/blood* | - |
dc.subject.MESH | Interleukin-6/metabolism | - |
dc.subject.MESH | Ischemia/blood* | - |
dc.subject.MESH | Ischemia/pathology* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Models, Statistical | - |
dc.subject.MESH | Phospholipids/chemistry | - |
dc.subject.MESH | Plasminogen Activator Inhibitor 1/blood | - |
dc.subject.MESH | Stroke/blood* | - |
dc.subject.MESH | Stroke/pathology* | - |
dc.subject.MESH | Thrombin/chemistry | - |
dc.subject.MESH | Thrombolytic Therapy | - |
dc.subject.MESH | Thrombosis | - |
dc.title | Plasma level of IL-6 and its relationship to procoagulant and fibrinolytic markers in acute ischemic stroke | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Laboratory Medicine (진단검사의학) | - |
dc.contributor.googleauthor | Jae Woo Song | - |
dc.contributor.googleauthor | Kyung Soon Song | - |
dc.contributor.googleauthor | Jong Rak Choi | - |
dc.contributor.googleauthor | Shin Young Kim | - |
dc.contributor.googleauthor | Ji-hyuk Rhee | - |
dc.identifier.doi | 10.3349/ymj.2006.47.2.201 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02011 | - |
dc.contributor.localId | A02054 | - |
dc.contributor.localId | A04182 | - |
dc.relation.journalcode | J02813 | - |
dc.identifier.eissn | 1976-2437 | - |
dc.identifier.pmid | 16642549 | - |
dc.subject.keyword | Stroke | - |
dc.subject.keyword | cytokine | - |
dc.subject.keyword | procoagulant | - |
dc.subject.keyword | fibrinolysis | - |
dc.contributor.alternativeName | Song, Kyung Soon | - |
dc.contributor.alternativeName | Song, Jae Woo | - |
dc.contributor.alternativeName | Choi, Jong Rak | - |
dc.contributor.affiliatedAuthor | Song, Kyung Soon | - |
dc.contributor.affiliatedAuthor | Song, Jae Woo | - |
dc.contributor.affiliatedAuthor | Choi, Jong Rak | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 47 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 201 | - |
dc.citation.endPage | 206 | - |
dc.identifier.bibliographicCitation | YONSEI MEDICAL JOURNAL, Vol.47(2) : 201-206, 2006 | - |
dc.identifier.rimsid | 50668 | - |
dc.type.rims | ART | - |
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