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Plasma level of IL-6 and its relationship to procoagulant and fibrinolytic markers in acute ischemic stroke

DC FieldValueLanguage
dc.contributor.author송경순-
dc.contributor.author송재우-
dc.contributor.author최종락-
dc.date.accessioned2015-06-10T12:29:20Z-
dc.date.available2015-06-10T12:29:20Z-
dc.date.issued2006-
dc.identifier.issn0513-5796-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/109894-
dc.description.abstractProcoagulant or impaired fibrinolytic states as well as inflammatory reactions mediated by cytokines are likely involved in the pathogenesis of acute ischemic stroke. We examined the potential relationship between interleukin 6 (IL-6) and hemostatic markers. The procoagulant and fibrinolytic states were assessed in 46 patients with acute stroke by measuring plasma levels of plasminogen activator inhibitor-1 (PAI-1), thrombin-antithrombin complex (TAT), and plasminogen-antiplasmin complex (PAP). Circulating IL-6 levels were measured using ELISA (Quantikine, R&D systems, MN, USA). Circulating IL-6 (mean, 26.5 pg/mL) and PAI-1 (mean, 19.9 ng/mL) levels were higher in patients with acute stroke than in healthy subjects (mean, 3.0 pg/mL, 10.4 ng/mL, respectively). TAT levels were statistically different according to the etiologic subtypes of stroke (atherogenic, 2.5 ng/mL; lacunar 3.2 ng/mL; cardiogenic 9.9 ng/mL, p = 0.021). Neither procoagulant levels nor fibrinolytic markers significantly correlated with circulating IL-6 levels. Our findings suggest that elevated proinflammatory cytokines during the initial hours of ischemic stroke may be an independent pathogenic factor or a consequence of the thrombotic event with no relationship to the procoagulant or fibrinolytic states.-
dc.description.statementOfResponsibilityopen-
dc.format.extent201~206-
dc.relation.isPartOfYONSEI MEDICAL JOURNAL-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAcute Disease-
dc.subject.MESHAged-
dc.subject.MESHAntithrombins/chemistry-
dc.subject.MESHBlood Coagulation Factors/metabolism-
dc.subject.MESHCoagulants/metabolism*-
dc.subject.MESHCytokines/metabolism-
dc.subject.MESHEnzyme-Linked Immunosorbent Assay-
dc.subject.MESHFemale-
dc.subject.MESHFibrinolysis*-
dc.subject.MESHHemostasis-
dc.subject.MESHHumans-
dc.subject.MESHInterleukin-6/blood*-
dc.subject.MESHInterleukin-6/metabolism-
dc.subject.MESHIschemia/blood*-
dc.subject.MESHIschemia/pathology*-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHModels, Statistical-
dc.subject.MESHPhospholipids/chemistry-
dc.subject.MESHPlasminogen Activator Inhibitor 1/blood-
dc.subject.MESHStroke/blood*-
dc.subject.MESHStroke/pathology*-
dc.subject.MESHThrombin/chemistry-
dc.subject.MESHThrombolytic Therapy-
dc.subject.MESHThrombosis-
dc.titlePlasma level of IL-6 and its relationship to procoagulant and fibrinolytic markers in acute ischemic stroke-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Laboratory Medicine (진단검사의학)-
dc.contributor.googleauthorJae Woo Song-
dc.contributor.googleauthorKyung Soon Song-
dc.contributor.googleauthorJong Rak Choi-
dc.contributor.googleauthorShin Young Kim-
dc.contributor.googleauthorJi-hyuk Rhee-
dc.identifier.doi10.3349/ymj.2006.47.2.201-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA02011-
dc.contributor.localIdA02054-
dc.contributor.localIdA04182-
dc.relation.journalcodeJ02813-
dc.identifier.eissn1976-2437-
dc.identifier.pmid16642549-
dc.subject.keywordStroke-
dc.subject.keywordcytokine-
dc.subject.keywordprocoagulant-
dc.subject.keywordfibrinolysis-
dc.contributor.alternativeNameSong, Kyung Soon-
dc.contributor.alternativeNameSong, Jae Woo-
dc.contributor.alternativeNameChoi, Jong Rak-
dc.contributor.affiliatedAuthorSong, Kyung Soon-
dc.contributor.affiliatedAuthorSong, Jae Woo-
dc.contributor.affiliatedAuthorChoi, Jong Rak-
dc.rights.accessRightsfree-
dc.citation.volume47-
dc.citation.number2-
dc.citation.startPage201-
dc.citation.endPage206-
dc.identifier.bibliographicCitationYONSEI MEDICAL JOURNAL, Vol.47(2) : 201-206, 2006-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers

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