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GnRH (Gonadotropin-Releasing Hormone)에 의한 자궁내막암 유래 세포주의 세포 증식 억제 기전에 있어서 Integrin, FAK (FocalAdhesion Kinase) 및 ERK (Extracellular Signal Regulated Kinase)의 역할
DC Field | Value | Language |
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dc.contributor.author | 최종락 | - |
dc.date.accessioned | 2015-06-10T12:29:06Z | - |
dc.date.available | 2015-06-10T12:29:06Z | - |
dc.date.issued | 2006 | - |
dc.identifier.issn | 1226-2951 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/109887 | - |
dc.description.abstract | Objective: To investigate new signal transduction cascade through integrin, FAK and ERK in the suppressed cell proliferation by GnRH-I and -II. Method: Human endometrial cancer cells (HEC1A) were cultured under the following condition: DMEM/F12 (10% FBS). GnRH-I and -II were treated time (0, 5, 10, 15, 20, 30 min; 100 nM) and dose (10 nM or 100 nM; 20 min) dependent manner according to experimental purposes. Cell proliferation was measured using [3H] thymidine incorporation assay. Immunoblotting was utilized to detect proteins. Results: GnRH-I and -II inhibited proliferation of HEC1A cells and induced expression of integrin β3. Phosphorylation of FAK and ERK were induced by GnRH-I and -II. Conclusion: GnRH inhibited cell proliferation via the expression of integrin and FAK, ERK phosphorylation. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 115~117 | - |
dc.language | Korean | - |
dc.publisher | 대한불임학회 | - |
dc.relation.isPartOf | Korean Journal of the Fertility and Sterility | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | GnRH (Gonadotropin-Releasing Hormone)에 의한 자궁내막암 유래 세포주의 세포 증식 억제 기전에 있어서 Integrin, FAK (FocalAdhesion Kinase) 및 ERK (Extracellular Signal Regulated Kinase)의 역할 | - |
dc.title.alternative | Role of Integrin, FAK (Focal Adhesion Kinase) and ERK (Extracellular Signal Regulated Kinase) on the Suppressed Cell Proliferation of Endometrial Cancer Cells by GnRH (Gonadotropin-Releasing Hormone) | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Laboratory Medicine (진단검사의학) | - |
dc.contributor.googleauthor | 최종락 | - |
dc.contributor.googleauthor | 박동욱 | - |
dc.contributor.googleauthor | 최동순 | - |
dc.contributor.googleauthor | 민철기 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A04182 | - |
dc.relation.journalcode | J02009 | - |
dc.subject.keyword | GnRH | - |
dc.subject.keyword | Integrin | - |
dc.subject.keyword | FAK | - |
dc.subject.keyword | ERK | - |
dc.subject.keyword | Phosphorylation | - |
dc.contributor.alternativeName | Choi, Jong Rak | - |
dc.contributor.affiliatedAuthor | Choi, Jong Rak | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 33 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 115 | - |
dc.citation.endPage | 117 | - |
dc.identifier.bibliographicCitation | Korean Journal of the Fertility and Sterility, Vol.33(2) : 115-117, 2006 | - |
dc.identifier.rimsid | 50663 | - |
dc.type.rims | ART | - |
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