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Integrins, membrane-type matrix metalloproteinases and ADAMs: potential implications for cardiac remodeling

Authors
 Ana Maria Manso  ;  Laila Elsherif  ;  Seok-Min Kang  ;  Robert S. Ross 
Citation
 CARDIOVASCULAR RESEARCH, Vol.69(3) : 574-584, 2006 
Journal Title
CARDIOVASCULAR RESEARCH
ISSN
 0008-6363 
Issue Date
2006
MeSH
Animals ; Disintegrins/metabolism ; Extracellular Matrix/enzymology* ; Extracellular Matrix/pathology ; Heart Failure/enzymology* ; Heart Failure/pathology ; Humans ; Integrins/physiology* ; Matrix Metalloproteinases/metabolism* ; Matrix Metalloproteinases, Membrane-Associated ; Myocardium/enzymology* ; Myocardium/pathology ; Ventricular Remodeling
Keywords
Metalloproteinases ; Membrane-type metalloproteinases ; Integrins ; ADAMs ; Disintergrins ; Cardiac remodeling
Abstract
The concept of myocardial remodeling links an initial pathological insult to a progressive geometric change of the ventricle. Currently, our concepts of the remodeling process have evolved to include not only changes in ventricular size and shape, but cellular and molecular remodeling, particularly as the ventricle evolves towards failure. In recent years, much attention has focused on the role of cell–extracellular matrix (ECM) connections in this process. In this review, we will specifically delineate how cell membrane-linked molecules of three classes: integrins, membrane-type matrix metalloproteinases, and ADAMs (A Disintegrin And Metalloproteinase) might play crucial roles in myocardial remodeling. These molecules are essential for cell–ECM adhesion, cell signaling, matrix modification, and proteolysis of surface receptors. Our goal is to put forth concepts on how they might interrelate to modulate the remodeling process in the heart.
Files in This Item:
T200600920.pdf Download
DOI
10.1016/j.cardiores.2005.09.004
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Seok Min(강석민) ORCID logo https://orcid.org/0000-0001-9856-9227
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/109869
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