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Enhanced Immunogenicity and Protective Efficacy with the Use of Interleukin-12-Encapsulated Microspheres plus AS01B in Tuberculosis Subunit Vaccination

Authors
 Sang-Jun Ha  ;  Su-Hyung Park  ;  Hye-Ju Kim  ;  Seung-Chul Kim  ;  Hyang-Ju Kang  ;  Eun-Gae Lee  ;  Soon-Geon Kwon  ;  Byong-Moon Kim  ;  Sung-Hee Lee  ;  Won-Bae Kim  ;  Young-Chul Sung  ;  Sang-Nae Cho 
Citation
 INFECTION AND IMMUNITY, Vol.74(8) : 4954-4959, 2006 
Journal Title
INFECTION AND IMMUNITY
ISSN
 0019-9567 
Issue Date
2006
MeSH
Acyltransferases/immunology ; Adjuvants, Immunologic* ; Animals ; Antibodies, Bacterial/blood* ; Antibodies, Bacterial/immunology ; Antigens, Bacterial/immunology ; Bacterial Proteins ; Capsules ; Delayed-Action Preparations ; Interleukin-12/immunology* ; Mice ; Mice, Inbred C57BL ; Microspheres* ; Mycobacterium tuberculosis/immunology ; Mycobacterium tuberculosis/pathogenicity ; Th1 Cells/immunology ; Tuberculosis/immunology ; Tuberculosis/prevention & control* ; Tuberculosis Vaccines/administration & dosage ; Tuberculosis Vaccines/immunology* ; Vaccination
Abstract
Tuberculosis subunit vaccines codelivered with interleukin-12 (IL-12)-encapsulated microspheres (IL-12EM) are designed for a sustained release of IL-12 and could induce strong Th1 immune responses specific to Ag85A and ESAT-6. The adjuvant combination of IL-12EM plus AS01B was a more efficient way to induce a sustained Th1 immunity and protection against Mycobacterium tuberculosis.
Files in This Item:
T200600914.pdf Download
DOI
10.1128/IAI.01781-05
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Microbiology (미생물학교실) > 1. Journal Papers
Yonsei Authors
Cho, Sang Nae(조상래)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/109863
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