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구강암 세포주에서 COX-2억제제에 의한 세포성장 억제 효과 및 세포사멸 기전 연구
DC Field | Value | Language |
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dc.contributor.author | 김진 | - |
dc.contributor.author | 이은주 | - |
dc.date.accessioned | 2015-06-10T12:26:26Z | - |
dc.date.available | 2015-06-10T12:26:26Z | - |
dc.date.issued | 2006 | - |
dc.identifier.issn | 1940-6207 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/109805 | - |
dc.description.abstract | Recently, prostaglandins have been reported to influence cell proliferation resulting in cancer development and progression. Prostaglandins are synthesized by cyclooxygenase (COX) pathway, COX-1 is constituently present in most cells and tissues where produce prostaglandins, while COX-2 expression is a critical part of inflammation and plays a major role in defending against exogenous stimuli. Moreover, COX-2 has been known to be related to cancer progression. Accordingly, cancer prevention trials have been applied by use of COX-2 inhibitors. Several putative targets have been proposed to account for NSAID-induced growth inhibition and apoptosis. This study was aimed at investigating the growth inhibitory effect and apoptosis mechanism by selective COX-2 inhibitor, celecoxib, in human oral squamous carcinoma cancer (OCC) cell lines. As a results, Celecoxib inhibited the growth of the cell lines in a dose dependent manner. Cell cycle kinetic analysis demonstrated that Celcoxib induces a delay in cll cycle progression and a G1 arrest. This induction of a G1 arrest was associated with the up-regulation of cyclin dependent kinase inhibitors (CDKI) p27KIP1 and P21CIP/WAF1. In adddition, 70 uM Celecoxib induced apoptosis through caspase-3 pathway. In conclusion, this study indicates that COX-2 specific inhibitor celecoxib induces apoptosis and cell cycle arrest in two oral squamous carcinoma cell lines. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 89~98 | - |
dc.relation.isPartOf | Cancer Prevention Research | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | 구강암 세포주에서 COX-2억제제에 의한 세포성장 억제 효과 및 세포사멸 기전 연구 | - |
dc.title.alternative | The Mechanism of Cell Growth Inhibition and Apoptosis by Cyclooxygenase-2 Inhibitior in Oral Squamous Carcinoma Cells | - |
dc.type | Article | - |
dc.contributor.college | College of Dentistry (치과대학) | - |
dc.contributor.department | Dept. of Oral Pathology (구강병리학) | - |
dc.contributor.googleauthor | 곽영은 | - |
dc.contributor.googleauthor | 김진 | - |
dc.contributor.googleauthor | 전남경 | - |
dc.contributor.googleauthor | 이은주 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A03049 | - |
dc.contributor.localId | A01009 | - |
dc.relation.journalcode | J00451 | - |
dc.subject.keyword | Oral squamous carcinoma cell lines | - |
dc.subject.keyword | Celecoxib | - |
dc.subject.keyword | Cell cycle | - |
dc.subject.keyword | Apoptosis | - |
dc.subject.keyword | Cyclooxygenase | - |
dc.contributor.alternativeName | Kim, Jin | - |
dc.contributor.alternativeName | Lee, Eun Ju | - |
dc.contributor.affiliatedAuthor | Lee, Eun Ju | - |
dc.contributor.affiliatedAuthor | Kim, Jin | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 11 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 89 | - |
dc.citation.endPage | 98 | - |
dc.identifier.bibliographicCitation | Cancer Prevention Research, Vol.11(2) : 89-98, 2006 | - |
dc.identifier.rimsid | 53430 | - |
dc.type.rims | ART | - |
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