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Effect of Plasma Exchange on the Circulating IL-6 Levels in a Patient With Fatal Hemophagocytic Syndrome Associated With Bile Ductopenia

Authors
 Kyung Soon Song  ;  Hyun Joo Sung 
Citation
 Therapeutics Apheresis and Dialysis, Vol.10(1) : 87-89, 2006 
Journal Title
 Therapeutics Apheresis and Dialysis 
ISSN
 1744-9979 
Issue Date
2006
MeSH
Adult ; Bile Ducts, Extrahepatic/pathology* ; Bilirubin/blood ; Cholestasis, Intrahepatic/complications ; Epstein-Barr Virus Infections/complications ; Fatal Outcome ; Humans ; Interleukin-6/blood* ; Lymphohistiocytosis, Hemophagocytic/blood ; Lymphohistiocytosis, Hemophagocytic/therapy* ; Male ; Plasma Exchange*
Keywords
Cytokine ; Epstein‐Barr virus ; Hemophagocytic syndrome ; Plasma exchange
Abstract
We report here the case of a patient suffering from hemophagocytic syndrome (HPS) associated with bile ductopenia. A 24-year old man was admitted after suffering fever, sore throat and general malaise for 7 days and jaundice for 2 days. Clinical studies showed hepatic dysfunction with hyperbilirubinemia. Epstein-Barr viral DNA from two bone marrow samples was detected. Bone marrow aspiration disclosed findings of HPS. Liver biopsy showed centrilobular cholestasis with lack of interlobular bile duct. Repeated therapeutic plasma exchange was effective for decreasing serum bilirubin and interleukin-6 levels. The patient received liver transplantation, however, he finally died of alveolar hemorrhage resulting from disseminated intravascular coagulation and acute rejection.
Full Text
http://onlinelibrary.wiley.com/doi/10.1111/j.1744-9987.2006.00347.x/abstract
DOI
10.1111/j.1744-9987.2006.00347.x
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
Yonsei Authors
Song, Kyung Soon(송경순)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/109789
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