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Helicobacter pylori 감염에서 새로운 저용량 13C-요소캡슐과 기존의 정제형 13C-요소제제를 이용한 요소호기검사간 비교

Other Titles
 Comparison Between a New Low Dose Urea Capsule Test and the Conventional UBiT TabletTest for the Detection of Helicobacter pylori Infection 
Authors
 박서진  ;  박윤희  ;  이상인  ;  이덕철  ;  용동은  ;  김정호 
Citation
 KOREAN JOURNAL OF LABORATORY MEDICINE , Vol.26(2) : 81-85, 2006 
Journal Title
 KOREAN JOURNAL OF LABORATORY MEDICINE 
ISSN
 1598-6535 
Issue Date
2006
Keywords
Urea breath test ; Helicobacter pylori ; Low-dose urea
Abstract
Background : The urea breath test (UBT) is regarded as a highly reliable, noninvasive tool for diagnosing Helicobacter pylori infection. We compared a recently developed low-dose 38 mg 13C-urea capsule, which is able to eliminate oral urease effects and does not require positional changes during the test, with the conventionally used 100 mg 13C-urea tablet method. Methods : Thirty-nine volunteers were tested under informed consent with both 13C-UBT methods, Helifinder and UBiT-IR300, with a minimum 2-week washout period. The pre-ingestion and 20- minute post-ingestion breath samples were analyzed with an isotope ratio mass spectrometer for Helifinder, and a nondispersive isotope-selective infrared spectrophotometer for UBiT samples. Results : Helifinder method showed excellent agreement with UBiT among 19 positive and 20 negative cases (weighted kappa value, 1.0). Helifinder results (y) showed good agreement but with a proportional bias compared to UBiT results (x) by Passing and Bablok method (y=0.551x-0.255, r=0.74, P<0.0001). Conclusion : Since the low-dose 38 mg 13C-urea capsule (Helifinder) test, which is more convenient and economic, showed comparable results with the conventional UBiT method, it can be used as an alternative for the diagnosis of H. pylori infection.
Files in This Item:
T200600818.pdf Download
DOI
10.3343/kjlm.2006.26.2.81
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Family Medicine (가정의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Jeong Ho(김정호) ORCID logo https://orcid.org/0000-0003-2479-0548
Yong, Dong Eun(용동은) ORCID logo https://orcid.org/0000-0002-1225-8477
Lee, Duk Chul(이덕철) ORCID logo https://orcid.org/0000-0001-9166-1813
Lee, Sang In(이상인)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/109750
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