Cited 46 times in
Collagen-based co-culture for invasive study on cancer cells-fibroblasts interaction
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김진 | - |
dc.contributor.author | 이은주 | - |
dc.date.accessioned | 2015-06-10T12:23:01Z | - |
dc.date.available | 2015-06-10T12:23:01Z | - |
dc.date.issued | 2006 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/109701 | - |
dc.description.abstract | The roles of tumor stroma in carcinogenesis are still unclear. This study was aimed at designing an in vitro model for investigating the effects of stromal fibroblasts in the invasive growth of squamous cell carcinoma. Using two cancer cell lines, we performed three-dimensional co-culture with dermal equivalents to evaluate the effects of fibroblasts in cancer invasion. In vitro models for cellular interaction study were designed as follows: a collagen gel-based direct co-culture model (C-Dr) and a collagen gel-based indirect co-culture model (C-In). The invasive growth was found only in the dermal equivalents with fibroblasts. MMP-2 activity could be induced by direct contact between cancer cells and stromal fibroblasts. Cathepsin D was also highly expressed when co-cultured with cancer cells and fibroblasts. The present study demonstrated that the presence of fibroblasts is essential in cancer invasion and that collagen gel-based co-culture models might be useful for invasive study. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 268~275 | - |
dc.relation.isPartOf | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Cathepsin D/biosynthesis | - |
dc.subject.MESH | Cell Communication | - |
dc.subject.MESH | Cell Line, Tumor | - |
dc.subject.MESH | Coculture Techniques/methods* | - |
dc.subject.MESH | Collagen/pharmacology* | - |
dc.subject.MESH | Fibroblasts/cytology* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Matrix Metalloproteinase 2/biosynthesis | - |
dc.subject.MESH | Matrix Metalloproteinase 9/biosynthesis | - |
dc.subject.MESH | Neoplasm Invasiveness/physiopathology* | - |
dc.subject.MESH | Stromal Cells/cytology* | - |
dc.title | Collagen-based co-culture for invasive study on cancer cells-fibroblasts interaction | - |
dc.type | Article | - |
dc.contributor.college | College of Dentistry (치과대학) | - |
dc.contributor.department | Dept. of Oral Pathology (구강병리학) | - |
dc.contributor.googleauthor | Zhong Min Che | - |
dc.contributor.googleauthor | Tae Heob Jung | - |
dc.contributor.googleauthor | Jung Hee Choi | - |
dc.contributor.googleauthor | Do Jun Yoon | - |
dc.contributor.googleauthor | Hyun Jeong Jeong | - |
dc.contributor.googleauthor | Eun Ju Lee | - |
dc.contributor.googleauthor | Jin Kim | - |
dc.identifier.doi | 10.1016/j.bbrc.2006.05.111 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A03049 | - |
dc.contributor.localId | A01009 | - |
dc.relation.journalcode | J00281 | - |
dc.identifier.eissn | 1090-2104 | - |
dc.identifier.pmid | 16756953 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0006291X06011727 | - |
dc.subject.keyword | Cancer cells-fibroblasts interaction | - |
dc.subject.keyword | Direct contact | - |
dc.subject.keyword | Indirect contact | - |
dc.subject.keyword | Collagen gel-based co-culture | - |
dc.subject.keyword | Matrix metalloproteinase | - |
dc.subject.keyword | Cathepsin D | - |
dc.contributor.alternativeName | Kim, Jin | - |
dc.contributor.alternativeName | Lee, Eun Ju | - |
dc.contributor.affiliatedAuthor | Lee, Eun Ju | - |
dc.contributor.affiliatedAuthor | Kim, Jin | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 346 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 268 | - |
dc.citation.endPage | 275 | - |
dc.identifier.bibliographicCitation | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Vol.346(1) : 268-275, 2006 | - |
dc.identifier.rimsid | 53366 | - |
dc.type.rims | ART | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.