Cited 122 times in
Intranasal delivery of the cytoplasmic domain of CTLA-4 using a novel protein transduction domain prevents allergic inflammation
DC Field | Value | Language |
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dc.contributor.author | 박중원 | - |
dc.date.accessioned | 2015-06-10T12:21:57Z | - |
dc.date.available | 2015-06-10T12:21:57Z | - |
dc.date.issued | 2006 | - |
dc.identifier.issn | 1078-8956 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/109668 | - |
dc.description.abstract | CTLA-4 is a negative regulator of T-cell activation, and its inhibitory effects can be accomplished either by competition with CD28 or by transmitting negative signals through its intracellular domain. To utilize the cytoplasmic domain of CTLA-4 to suppress allergic inflammation, we fused it to a novel protein-transduction domain in the human transcriptional factor Hph-1. Transduction efficiency was verified in vitro and in vivo after ocular, intranasal and intradermal administration. After transduction into T cells, the Hph-1-ctCTLA-4 fusion protein inhibited the production of interleukin (IL)-2, and downregulated CD69 and CD25. Intranasal administration of Hph-1-ctCTLA-4 resulted in markedly reduced infiltration of inflammatory cells, secretion of T helper type 2 (T(H)2) cytokines, serum IgE levels and airway hyper-responsiveness in a mouse model of allergic airway inflammation. These results indicated that Hph-1-ctCTLA-4 constitutes an effective immunosuppressive protein drug for potential use in the treatment of allergic asthma, via nasal administration. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 574~579 | - |
dc.relation.isPartOf | NATURE MEDICINE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Administration, Intranasal* | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Antigens, CD | - |
dc.subject.MESH | Antigens, Differentiation/administration & dosage* | - |
dc.subject.MESH | Antigens, Differentiation/genetics | - |
dc.subject.MESH | Antigens, Differentiation/immunology* | - |
dc.subject.MESH | Asthma*/immunology | - |
dc.subject.MESH | Asthma*/prevention & control | - |
dc.subject.MESH | Bronchial Hyperreactivity | - |
dc.subject.MESH | CTLA-4 Antigen | - |
dc.subject.MESH | Carrier Proteins/genetics | - |
dc.subject.MESH | Carrier Proteins/metabolism* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Immunoconjugates/administration & dosage | - |
dc.subject.MESH | Immunoconjugates/genetics | - |
dc.subject.MESH | Immunoconjugates/immunology | - |
dc.subject.MESH | Immunosuppressive Agents*/administration & dosage | - |
dc.subject.MESH | Immunosuppressive Agents*/immunology | - |
dc.subject.MESH | Inflammation*/immunology | - |
dc.subject.MESH | Inflammation*/prevention & control | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Mice, Inbred BALB C | - |
dc.subject.MESH | Ovalbumin/immunology | - |
dc.subject.MESH | Polycomb Repressive Complex 1 | - |
dc.subject.MESH | Protein Structure, Tertiary | - |
dc.subject.MESH | Recombinant Fusion Proteins/administration & dosage | - |
dc.subject.MESH | Recombinant Fusion Proteins/genetics | - |
dc.subject.MESH | Recombinant Fusion Proteins/immunology | - |
dc.subject.MESH | Transduction, Genetic | - |
dc.title | Intranasal delivery of the cytoplasmic domain of CTLA-4 using a novel protein transduction domain prevents allergic inflammation | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Je-Min Choi | - |
dc.contributor.googleauthor | Mi-Hyun Ahn | - |
dc.contributor.googleauthor | Wook-Jin Chae | - |
dc.contributor.googleauthor | Yung-Gook Jung | - |
dc.contributor.googleauthor | Jae-Chul Park | - |
dc.contributor.googleauthor | Hyun-Mi Song | - |
dc.contributor.googleauthor | Young-Eun Kim | - |
dc.contributor.googleauthor | Jung-Ah Shin | - |
dc.contributor.googleauthor | Choon-Sik Park | - |
dc.contributor.googleauthor | Jung-Won Park | - |
dc.contributor.googleauthor | Tae-Kwann Park | - |
dc.contributor.googleauthor | Jung-Hoon Lee | - |
dc.contributor.googleauthor | Byung-Fhy Seo | - |
dc.contributor.googleauthor | Kyun-Do Kim | - |
dc.contributor.googleauthor | Eun-Sung Kim | - |
dc.contributor.googleauthor | Dong-Ho Lee | - |
dc.contributor.googleauthor | Seung-Kyou Lee | - |
dc.contributor.googleauthor | Sang-Kyou Lee | - |
dc.identifier.doi | 10.1038/nm1385 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01681 | - |
dc.relation.journalcode | J02296 | - |
dc.identifier.eissn | 1546-170X | - |
dc.identifier.pmid | 16604087 | - |
dc.identifier.url | http://www.nature.com/nm/journal/v12/n5/full/nm1385.html | - |
dc.contributor.alternativeName | Park, Jung Won | - |
dc.contributor.affiliatedAuthor | Park, Jung Won | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 12 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 574 | - |
dc.citation.endPage | 579 | - |
dc.identifier.bibliographicCitation | NATURE MEDICINE, Vol.12(5) : 574-579, 2006 | - |
dc.identifier.rimsid | 38907 | - |
dc.type.rims | ART | - |
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