Cited 95 times in
Serial Transverse Enteroplasty Enhances Intestinal Function In a Model of Short Bowel Syndrome
DC Field | Value | Language |
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dc.contributor.author | 오정탁 | - |
dc.date.accessioned | 2015-06-10T12:21:22Z | - |
dc.date.available | 2015-06-10T12:21:22Z | - |
dc.date.issued | 2006 | - |
dc.identifier.issn | 0003-4932 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/109651 | - |
dc.description.abstract | OBJECTIVE/SUMMARY BACKGROUND DATA: Serial transverse enteroplasty (STEP) is a new intestinal lengthening procedure that has been shown to clinically increase bowel length. This study examined the impact of the STEP procedure upon intestinal function in a model of short bowel syndrome. METHODS: Young pigs (n=10) had a reversed segment of bowel interposed to induce bowel dilatation. Five pigs underwent a 90% bowel resection with a STEP procedure on the remaining dilated bowel while 5 served as controls and had a 90% bowel resection without a STEP procedure. Determinations of nutritional status, absorptive capacity, and bacterial overgrowth were conducted 6 weeks after resection. Statistical comparisons were made by 2-sample t test (significance at P<0.05). RESULTS: The STEP procedure lengthened the bowel from 105.2+/-7.7 cm to 152.2+/-8.3 cm (P<0.01). The STEP animals showed improved weight retention compared with controls (mean, -0.5%+/-1.8% body weight versus -17.6%+/-1.5%, P<0.001). Intestinal carbohydrate absorption, as measured by d-Xylose absorption and fat absorptive capacity as measured by serum vitamin D and triglyceride levels, were increased in the STEP group versus controls. Serum citrulline, a marker of intestinal mucosal mass, was significantly elevated in the STEP pigs compared with controls. None of the STEP animals but 4 of 5 control animals were noted to have gram-negative bacterial overgrowth in the proximal bowel. CONCLUSIONS: STEP improves weight retention, nutritional status, intestinal absorptive capacity, and serum citrulline levels in a porcine short bowel model. A salutary effect upon bacterial overgrowth was also noted. These data support the use of this operation in short bowel syndrome. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 223~228 | - |
dc.relation.isPartOf | ANNALS OF SURGERY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Anastomosis, Surgical/methods | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Dilatation, Pathologic | - |
dc.subject.MESH | Disease Models, Animal | - |
dc.subject.MESH | Intestines/microbiology | - |
dc.subject.MESH | Short Bowel Syndrome/surgery* | - |
dc.subject.MESH | Surgical Stapling | - |
dc.subject.MESH | Swine | - |
dc.title | Serial Transverse Enteroplasty Enhances Intestinal Function In a Model of Short Bowel Syndrome | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Surgery (외과학) | - |
dc.contributor.googleauthor | Robert W. Chang | - |
dc.contributor.googleauthor | Patrick J. Javid | - |
dc.contributor.googleauthor | Jung-Tak Oh | - |
dc.contributor.googleauthor | Steven Andreoli | - |
dc.contributor.googleauthor | Heung Bae Kim | - |
dc.contributor.googleauthor | Dario Fauza | - |
dc.contributor.googleauthor | Tom Jaksic | - |
dc.identifier.doi | 10.1097/01.sla.0000197704.76166.07 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02397 | - |
dc.relation.journalcode | J00178 | - |
dc.identifier.eissn | 1528-1140 ( | - |
dc.identifier.pmid | 16432355 | - |
dc.contributor.alternativeName | Oh, Jung Tak | - |
dc.contributor.affiliatedAuthor | Oh, Jung Tak | - |
dc.contributor.affiliatedAuthor | 오정탁 | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 243 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 223 | - |
dc.citation.endPage | 228 | - |
dc.identifier.bibliographicCitation | ANNALS OF SURGERY, Vol.243(2) : 223-228, 2006 | - |
dc.identifier.rimsid | 38896 | - |
dc.type.rims | ART | - |
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