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The N Ratio Predicts Recurrence and Poor Prognosis in Patients With Node-Positive Early Gastric Cancer

DC Field Value Language
dc.contributor.author노성훈-
dc.contributor.author송창수-
dc.contributor.author정재호-
dc.contributor.author최승호-
dc.contributor.author형우진-
dc.date.accessioned2015-06-10T12:19:42Z-
dc.date.available2015-06-10T12:19:42Z-
dc.date.issued2006-
dc.identifier.issn1068-9265-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/109599-
dc.description.abstractBACKGROUND: The metastatic status of the regional node is the most significant prognostic factor for early gastric cancer (EGC). However, diverse prognoses are evident even among the same N classifications of the current tumor-node-metastasis system. The aim of this study was to evaluate the prognostic significance of the ratio of metastatic to retrieved lymph nodes (N ratio) in identifying a high-risk subgroup with node-positive EGC. METHODS: From a prospective database of 1264 EGC patients between 1987 and 1997, 156 (12.4%) were found to have histologically confirmed node metastasis. A number of prognostic factors, including the N ratio, were evaluated by univariate and multivariate analysis. RESULTS: The recurrence rate of node-positive EGC was 16.7% (n = 26). The overall 5-year survival rate of all patients was 84.0%. It was 26.9% and 95.4% in patients with and without recurrence, respectively (P < .0001; log-rank test). The cutoff value of the N ratio was set at .07. The 5-year survival rate of patients with an N ratio <.07 was 94.0%; this was significantly higher than the rate (72.6%) for those with a ratio >.07 (P < .0001; log-rank test). Both univariate and multivariate analysis identified the N ratio as the most significant predictive factor for recurrence and overall survival. Regarding stage migration, it shows superiority in comparison to the number-based N classification. CONCLUSIONS: The N ratio is a more effective and rational indicator for prognostic stratification of patients with lymph node-positive EGC than the current N classification of the tumor-node-metastasis system.-
dc.description.statementOfResponsibilityopen-
dc.format.extent377~385-
dc.relation.isPartOfANNALS OF SURGICAL ONCOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHFemale-
dc.subject.MESHFollow-Up Studies-
dc.subject.MESHHumans-
dc.subject.MESHLymphatic Metastasis*-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHNeoplasm Recurrence, Local*-
dc.subject.MESHNeoplasm Staging/methods*-
dc.subject.MESHPrognosis-
dc.subject.MESHStomach Neoplasms/pathology*-
dc.subject.MESHStomach Neoplasms/surgery-
dc.subject.MESHSurvival Analysis-
dc.titleThe N Ratio Predicts Recurrence and Poor Prognosis in Patients With Node-Positive Early Gastric Cancer-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Surgery (외과학)-
dc.contributor.googleauthorJae-Ho Cheong-
dc.contributor.googleauthorWoo Jin Hyung-
dc.contributor.googleauthorJian Guo Shen-
dc.contributor.googleauthorChangsoo Song-
dc.contributor.googleauthorJunuk Kim-
dc.contributor.googleauthorSeung Ho Choi-
dc.contributor.googleauthorSung Hoon Noh-
dc.identifier.doi10.1245/ASO.2006.04.018-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA04102-
dc.contributor.localIdA01281-
dc.contributor.localIdA02070-
dc.contributor.localIdA03717-
dc.contributor.localIdA04382-
dc.relation.journalcodeJ00179-
dc.identifier.eissn1534-4681-
dc.identifier.pmid16450215-
dc.identifier.urlhttp://link.springer.com/article/10.1245%2FASO.2006.04.018-
dc.subject.keywordEarly gastric cancer-
dc.subject.keywordLymph node metastasis-
dc.subject.keywordMetastatic lymph node ratio-
dc.subject.keywordPrognosis Recurrence-
dc.contributor.alternativeNameNoh, Sung Hoon-
dc.contributor.alternativeNameSong, Chang Soo-
dc.contributor.alternativeNameCheong, Jae Ho-
dc.contributor.alternativeNameChoi, Seung Ho-
dc.contributor.alternativeNameHyung, Woo Jin-
dc.contributor.affiliatedAuthorChoi, Seung Ho-
dc.contributor.affiliatedAuthorNoh, Sung Hoon-
dc.contributor.affiliatedAuthorSong, Chang Soo-
dc.contributor.affiliatedAuthorCheong, Jae Ho-
dc.contributor.affiliatedAuthorHyung, Woo Jin-
dc.rights.accessRightsnot free-
dc.citation.volume13-
dc.citation.number3-
dc.citation.startPage377-
dc.citation.endPage385-
dc.identifier.bibliographicCitationANNALS OF SURGICAL ONCOLOGY, Vol.13(3) : 377-385, 2006-
dc.identifier.rimsid38857-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers

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