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아토피피부염 환아에서 CTLA-4 exon 1과 promoter 유전자 다형성
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김경원 | - |
dc.contributor.author | 김규언 | - |
dc.contributor.author | 김은수 | - |
dc.contributor.author | 손명현 | - |
dc.contributor.author | 송태원 | - |
dc.date.accessioned | 2015-06-10T12:19:30Z | - |
dc.date.available | 2015-06-10T12:19:30Z | - |
dc.date.issued | 2006 | - |
dc.identifier.issn | 1738-1061 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/109593 | - |
dc.description.abstract | Purpose: The gene-encoding cytotoxic T lymphocyte-associated antigen-4(CTLA-4) is one of the candidate genes for conferring susceptibility to atopic dermatitis(AD). The aim of the study was to investigate the association between Korean children with AD and the polymorphisms of CTLA-4 gene promoter(-318) and exon 1(+49). Methods: The CTLA-4 promoter(-318 T/C) and exon 1(+49 A/G) polymorphisms were genotyped via restriction fragment length polymorphism methods in 145 children with atopic eczema, 69 children with non-atopic eczema, and 96 healthy controls. Results: There was no significant difference in genotype and allele frequencies of the CTLA-4 promoter -318 T/C and exon 1 +49 A/G polymorphisms when the atopic eczema, non-atopic eczema, and control groups were compared. Additionally the CTLA-4 promoter -318 T/C and exon 1 +49 A/G polymorphisms were not shown to be associated with severity, IgE level, or eosinophil counts. Conclusion: Our data show that the polymorphisms within the CTLA-4 promoter(-318 T/C) and exon 1(+49 A/G) genes are not associated with susceptibility to AD in Korean children. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 545~551 | - |
dc.language | Korean | - |
dc.publisher | 대한소아과학회 | - |
dc.relation.isPartOf | Korean Journal of Pediatrics | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | 아토피피부염 환아에서 CTLA-4 exon 1과 promoter 유전자 다형성 | - |
dc.title.alternative | Polymorphisms of the CTLA-4 promoter(-318) and exon 1(+49) genes with atopic dermatitis in Korean children | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pediatrics (소아과학) | - |
dc.contributor.googleauthor | 송태원 | - |
dc.contributor.googleauthor | 양혜선 | - |
dc.contributor.googleauthor | 이경은 | - |
dc.contributor.googleauthor | 김경원 | - |
dc.contributor.googleauthor | 김은수 | - |
dc.contributor.googleauthor | 손명현 | - |
dc.contributor.googleauthor | 김규언 | - |
dc.identifier.doi | 10.3345/kjp.2006.49.5.545 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00805 | - |
dc.contributor.localId | A00303 | - |
dc.contributor.localId | A00327 | - |
dc.contributor.localId | A01967 | - |
dc.contributor.localId | A02072 | - |
dc.relation.journalcode | J02100 | - |
dc.identifier.eissn | 2092-7258 | - |
dc.subject.keyword | Atopic dermatitis | - |
dc.subject.keyword | CTLA-4 | - |
dc.subject.keyword | Polymorphism | - |
dc.contributor.alternativeName | Kim, Kyung Won | - |
dc.contributor.alternativeName | Kim, Kyu Earn | - |
dc.contributor.alternativeName | Kim, Eun Soo | - |
dc.contributor.alternativeName | Son, Myung Hyun | - |
dc.contributor.alternativeName | Song, Tae Won | - |
dc.contributor.affiliatedAuthor | Kim, Eun Soo | - |
dc.contributor.affiliatedAuthor | Kim, Kyung Won | - |
dc.contributor.affiliatedAuthor | Kim, Kyu Earn | - |
dc.contributor.affiliatedAuthor | Son, Myung Hyun | - |
dc.contributor.affiliatedAuthor | Song, Tae Won | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 49 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 545 | - |
dc.citation.endPage | 551 | - |
dc.identifier.bibliographicCitation | Korean Journal of Pediatrics, Vol.49(5) : 545-551, 2006 | - |
dc.identifier.rimsid | 45312 | - |
dc.type.rims | ART | - |
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