크레메진의 투석도입 지연효과에 따른 진행성 신부전증환자의 비용감소분 추계

Abstract

Objectives: We wanted to evaluate the economic value of a pharmaceutical product, Kremezin, for treating patients with chronic renal failure (CRF) by estimating the amount of cost savings due to its effect for delaying the initiation of dialysis treatments.

Methods: We defined a conventional treatment for CRF accompanied by Kremezin therapy as ’the treatment group’ and only conventional treatment as ’the alternative group.’ The types of costs included were direct medical and nonmedical costs and costs of productivity loss. The information on the effect of Kremezin was obtained from the results of earlier clinical studies. Cost information was derived from the administrative data for 20 hemodialysis and 20 peritoneal dialysis patients from one tertiary care hospital, and also from the administrative data of 10 hemodialysis patients from one free-standing dialysis center. Per-capita cost savings resulting from Kremezin therapy were separately estimated for the cases with delay for the onset of hemodialysis and the cases with immediate performance of peritoneal dialysis. By computing the weighted average for the cases of hemodialysis and peritoneal dialysis, the expected per-capita cost savings of a patient with CRF was obtained. Using a discount rate of 5%, future cost savings were converted to the present value.

Results: The present value of cumulative cost savings per patient with CRF from the societal perspective would be 18,555,000-29,410,000 Won or 72,104,000-112,523,000 Won if Kremezin delays the initiation of dialysis by 1 or 4 years.

Conclusions : The estimated amount of cost savings resulting from treating CRF patients with Kremezin confirms that its effect for delaying the onset of dialysis treatments has a considerable economic value.