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이식 전 B형 간염 표면항원 양성인 환자에서 시행한 신장이식 후 임상 경과
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김명수 | - |
dc.contributor.author | 김순일 | - |
dc.contributor.author | 김유선 | - |
dc.date.accessioned | 2015-06-10T12:18:00Z | - |
dc.date.available | 2015-06-10T12:18:00Z | - |
dc.date.issued | 2006 | - |
dc.identifier.issn | 1298-1711 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/109547 | - |
dc.description.abstract | Purpose: The natural history of renal transplant recipients with positive HBs Ag is still unclear and unpredictable. Liver-related morbidity and mortality after long-term immunosuppression need clinical challenges. We retrospectively investigated the clinical outcome of pre-transplant HBs Ag positive renal recipients in a single transplant center located in endemic area. Methods: After excluding post-transplant de novo HBV infected, and peri-transplant anti-hepatitis C virus positive recipients, the clinical outcome of 1,816 recipients was examined by the nature of pre-transplant HBs Ag positivity. Results: Pre-transplant HBs Ag positivity was documented in 61 recipients (M/F=47/14). During mean follow up of 71.61±54.14 months, 24 recipients died (6 by infection, 12 by hepatic failure, 2 by hepatocellular carcinoma, 2 by other malignancies, 1 by suicide, 1 by gastrointestinal bleeding). In 14 recipients (58.3%), death was related to liver-associated reasons. The 10-year patient survival rates in HBs Ag negative and positive groups were 90.0% and 62.6%, respectively (P<0.0001). The 10-year graft survival rates in HBs Ag negative and positive groups were 82.0% and 55.6%, respectively (P<0.0001). When pre-transplant HBV DNA viral load by PCR was positive or when the level of post-transplant HBV-DNA viral load flared up, we started lamivudine therapy since 1997. Seventeen recipients received daily 100 mg lamivudine. The mean duration of patients survival with (n=17) and without (n=44) lamivudine therapy was 104.3±45.6 and 59.0±51.2 months, respectively (P=0.003). The 10-year patient survival rates in patients with and without lamivudine therapy were 80.7% and 55.4%, respectively (P=0.0698). Conclusion: Overall patient and graft survival in patients with positive pre-transplant HBs Ag was lower than negative recipients. Although, statistically not significant, lamivudine therapy showed a marginally positive impact on the survival of patients with pre-transplant positive HBs Ag. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.language | Journal of the Korean Society for Transplantation | - |
dc.publisher | Journal of the Korean Society for Transplantation | - |
dc.relation.isPartOf | Journal of the Korean Society for Transplantation | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | 이식 전 B형 간염 표면항원 양성인 환자에서 시행한 신장이식 후 임상 경과 | - |
dc.title.alternative | Clinical Outcome of Renal Transplantation in Patients with Positive Pretransplant Hepatitis B Surface Antigen | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Surgery (외과학) | - |
dc.contributor.googleauthor | 안형준 | - |
dc.contributor.googleauthor | 김명수 | - |
dc.contributor.googleauthor | 김순일 | - |
dc.contributor.googleauthor | 이종훈 | - |
dc.contributor.googleauthor | 주만기 | - |
dc.contributor.googleauthor | 김유선 | - |
dc.contributor.googleauthor | 전경옥 | - |
dc.contributor.googleauthor | 김현정 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00424 | - |
dc.contributor.localId | A00649 | - |
dc.contributor.localId | A00785 | - |
dc.relation.journalcode | J01858 | - |
dc.identifier.eissn | 2508-2604 | - |
dc.subject.keyword | Pre-transplant HBs antigen | - |
dc.subject.keyword | Renal transplantation | - |
dc.subject.keyword | Lamivudine | - |
dc.contributor.alternativeName | Kim, Myoung Soo | - |
dc.contributor.alternativeName | Kim, Soon Il | - |
dc.contributor.alternativeName | Kim, Yu Seun | - |
dc.contributor.affiliatedAuthor | Kim, Myoung Soo | - |
dc.contributor.affiliatedAuthor | Kim, Soon Il | - |
dc.contributor.affiliatedAuthor | Kim, Yu Seun | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 20 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 79 | - |
dc.citation.endPage | 83 | - |
dc.identifier.bibliographicCitation | Journal of the Korean Society for Transplantation, Vol.20(1) : 79-83, 2006 | - |
dc.identifier.rimsid | 45281 | - |
dc.type.rims | ART | - |
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