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흰 쥐 신장의 허혈 재관류 손상에서 α-melanocyte stimulating hormone의 효과
DC Field | Value | Language |
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dc.contributor.author | 김유선 | - |
dc.date.accessioned | 2015-06-10T12:17:54Z | - |
dc.date.available | 2015-06-10T12:17:54Z | - |
dc.date.issued | 2006 | - |
dc.identifier.issn | 1298-1711 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/109544 | - |
dc.description.abstract | Purpose: In ischemia-reperfusion induced renal injuries, cytokines, chemoattractant chemokines, adhesion molecules and nitric oxide play an important role. α-Melanocyte stimulating hormone (α-MSH) is a potent anti-inflammatory cytokine so the therapeutic effect of α-MSH on an ischemia-reperfusion induced acute renal failure is to be evaluated. Methods: 40 male Spraque-Dawley rats were prepared for the experiment, they were classified into three classes (Sham, ischemic control and α-MSH injection). Both renal pedicles were clamped for 45 minutes. α-MSH (50㎍) was injected intravenously three times, immediately before ischemia and reperfusion and 18 hour after reperfusion. Serum creatinine and histologic changes were analyzed between groups (Sham (n=6), ischemic control group (n=15), and α-MSH group (n=19)). Results: Serum creatinine level decreased significantly at 24 hours after reperfusion in α-MSH treated animals (SCr24 0.78±0.23㎎/dL 4.21±1.14㎎/dL, 3.01±1.19㎎/dL, repectively (P=0.008)), especially serum creatinine level at 48 hours after reperfusion much more dicreased in α-MSH group (SCr48 0.67±0.16㎎/dL, 4.21±2.03㎎/dL, 1.15±1.11㎎/dL, repectively (P=0.004)). Tubular neccrosis and neutrophil infiltration decreased signigicantly in α-MSH treated group (P=0.001). Mortality was noted 33.3% only at ischemic conrol group. Conclusion: we demonstrate the fact that α-MSH has protective role on ischemic renal injury and improves survival rates. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.language | Journal of the Korean Society for Transplantation | - |
dc.publisher | Journal of the Korean Society for Transplantation | - |
dc.relation.isPartOf | Journal of the Korean Society for Transplantation | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | 흰 쥐 신장의 허혈 재관류 손상에서 α-melanocyte stimulating hormone의 효과 | - |
dc.title.alternative | The Effect of α-Melanocyte Stimulating Hormone on Renal Ischemia Reperfusion Injury | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Surgery (외과학) | - |
dc.contributor.googleauthor | 염차경 | - |
dc.contributor.googleauthor | 진준우 | - |
dc.contributor.googleauthor | 정구용 | - |
dc.contributor.googleauthor | 성순희 | - |
dc.contributor.googleauthor | 한기환 | - |
dc.contributor.googleauthor | 강은숙 | - |
dc.contributor.googleauthor | 김유선 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00785 | - |
dc.relation.journalcode | J01858 | - |
dc.identifier.eissn | 2508-2604 | - |
dc.subject.keyword | Ischemia-reperfusion injury | - |
dc.subject.keyword | Acute renal failure | - |
dc.subject.keyword | α-MSH | - |
dc.contributor.alternativeName | Kim, Yu Seun | - |
dc.contributor.affiliatedAuthor | Kim, Yu Seun | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 20 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 49 | - |
dc.citation.endPage | 54 | - |
dc.identifier.bibliographicCitation | Journal of the Korean Society for Transplantation, Vol.20(1) : 49-54, 2006 | - |
dc.identifier.rimsid | 45279 | - |
dc.type.rims | ART | - |
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