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아급성기 뇌졸중 환자의 인지 기능 저하에서 donepezil의 효과

Other Titles
 The Efficacy of Donepezil on Cognitive Dysfunction in Subacute Post-stroke Patients 
 김덕용  ;  박창일  ;  온석훈  ;  양은주  ;  안소영  ;  나상일 
 Journal of the Korean Academy of Rehabilitation Medicine (대한재활의학회지), Vol.30(2) : 111-115, 2006 
Journal Title
Journal of the Korean Academy of Rehabilitation Medicine(대한재활의학회지)
Issue Date
Donepezil ; Cognitive function ; Memory ; Stroke
Objective: To evaluate the efficacy of donepezil on cognitive dysfunction in subacute post-stroke patients. Methods: Sixty subacute stroke subjects were enrolled and randomly assigned into an experimental or control group. There was no significant difference between the two groups in age, sex and post-onset duration. Donepezil 5 mg was administered daily for 6 weeks to patients in the experimental group. Mini-Mental Status Examination (MMSE), Wechsler Memory Test (WMT) and Colored Progressive Matrices (CPM) were performed before and 6 weeks after administration of the study drug in both groups. Results: There was no difference between the two groups in the MMSE, WMT, CPM scores at baseline. Six weeks later, the total score, memory input, recall and judgement as measured by the MMSE and the score on the WMT were significantly more improved in the experimental group when compared to the control group (p<0.05). However, there was no significant difference between the two groups on the CPM score. Conclusion: These results suggested that donepezil may be helpful for improving cognitive function, especially memory in post-stroke patients.
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Rehabilitation Medicine (재활의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Deog Young(김덕용) ORCID logo https://orcid.org/0000-0001-7622-6311
Park, Chang Il(박창일)
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