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Respiratory muscle strength and cough capacity in patients with Duchenne muscular dystrophy

Authors
 Seong-Woong Kang  ;  Yeoun-Seung Kang  ;  Hong-Seok Sohn  ;  Jung-Hyun Park  ;  Jae-Ho Moon 
Citation
 YONSEI MEDICAL JOURNAL, Vol.47(2) : 184-190, 2006 
Journal Title
YONSEI MEDICAL JOURNAL
ISSN
 0513-5796 
Issue Date
2006
MeSH
Adolescent ; Adult ; Biopsy ; Cough ; Humans ; Inspiratory Capacity ; Male ; Models, Statistical ; Muscle Weakness/pathology ; Muscles/pathology ; Muscular Dystrophy, Duchenne/genetics* ; Oxygen Consumption* ; Pressure ; Respiratory Muscles/pathology*
Keywords
Duchenne muscular dystrophy ; cough ; assisted cough ; peak cough flow ; maximal inspiratory pressure ; maximal expiratory pressure
Abstract
The function of inspiratory muscles is crucial for effective cough as well as expiratory muscles in patients with Duchenne muscular dystrophy (DMD). However, there is no report on the correlation between cough and inspiratory muscle strength. To investigate the relationships of voluntary cough capacity, assisted cough techniques, and inspiratory muscle strength as well as expiratory muscle strength in patients with DMD (n = 32). The vital capacity (VC), maximum insufflation capacity (MIC), maximal inspiratory pressure (MIP), and maximal expiratory pressure (MEP) were measured. Unassisted peak cough flow (UPCF) and three different techniques of assisted PCF were evaluated. The mean value of MICs (1918 ± 586 mL) was higher than that of VCs (1474 ± 632 mL) (p < 0.001). All three assisted cough methods showed significantly higher value than unassisted method (212 ± 52 L/min) (F = 66.13, p < 0.001). Combined assisted cough technique (both manual and volume assisted PCF; 286 ± 41 L/min) significantly exceeded manual assisted PCF (MPCF; 246 ± 49 L/min) and volume assisted PCF (VPCF; 252 ± 45 L/min) (F = 66.13, p < 0.001). MIP (34 ± 13 cmH2O) correlated significantly with both UPCF and all three assisted PCFs as well as MEP (27 ± 10 cmH2O) (p < 0.001). Both MEP and MIP, which are the markers of respiratory muscle weakness, should be taken into account in the study of cough effectiveness.
Files in This Item:
T200600548.pdf Download
DOI
10.3349/ymj.2006.47.2.184
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Rehabilitation Medicine (재활의학교실) > 1. Journal Papers
Yonsei Authors
Kang, Seong Woong(강성웅) ORCID logo https://orcid.org/0000-0002-7279-3893
Moon, Jae Ho(문재호)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/109421
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